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Adverse Drug Reactions in Elderly Inpatients: Comparison with Younger Patients

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dc.contributor.author김, 정은-
dc.contributor.author견, 진옥-
dc.contributor.author진, 선민-
dc.contributor.author이, 영희-
dc.contributor.author김, 주희-
dc.contributor.author이, 현영-
dc.contributor.author박, 해심-
dc.contributor.author최, 영화-
dc.contributor.author예, 영민-
dc.description.abstractBackground: There have been few reports on the characteristics of adverse drug reactions (ADRs) in elderly patients among the Korean population.

Objective: To investigate the characteristics of ADRs in elderly patients compared with those in younger ones.

Method: ADRs were collected from a spontaneous reporting system at our university hospital in 2008. Characteristics including underlying diseases, duration of hospitalization, clinical manifestations, culprit drugs and number of concomitant medications were compared between the young (<65 years) and elderly (≥65 years) groups.

Result: A total of 528 ADRs occurred in 513 patients, and 120 ADRs (22.7%) occurred in 116 elderly patients. Their

mean age was 71.6 years. Antibiotics (45.8%) were the most common culprit drugs. The prevalence of ADRs due

to cardiovascular drugs was significantly higher in the elderly group (9.2%) than in the young group (2.9%, P=0.003). The most prevalent clinical types were skin manifestations (40.5%), gastrointestinal abnormalities (28.4%) and systemic reactions (23.5%) in both groups. Renal function abnormalities were significantly more prevalent in the elderly group (4.2%) than in the young group (0.5%, P=0.008). The mean number of concomitant medications was significantly higher in the elderly group (6.5±4.6) than in the young group (1.9±3.9).

Conclusion: For the early detection of ADRs in elderly patients, close monitoring of cardiovascular drug use and

renal function are recommended.
dc.titleAdverse Drug Reactions in Elderly Inpatients: Comparison with Younger Patients-
dc.title.alternative노인 입원환자에서 발생한 약물유해반응의 특성-
dc.subject.keywordAdverse drug reaction reporting systems-
dc.subject.keywordCardiovascular agents-
dc.contributor.affiliatedAuthor김, 정은-
dc.contributor.affiliatedAuthor김, 주희-
dc.contributor.affiliatedAuthor박, 해심-
dc.contributor.affiliatedAuthor최, 영화-
dc.contributor.affiliatedAuthor예, 영민-
dc.type.localJournal Papers-
dc.citation.titleChʿŏnsik mit alrerugi-
dc.citation.titleJournal of asthma, allergy and clinical immunology-
dc.citation.titleKorean journal of asthma, allergy and clinical immunology-
dc.citation.title천식 및 알레르기-
dc.identifier.bibliographicCitationChʿŏnsik mit alrerugi, 30(3):216-221, 2010-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Infectious Diseases
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
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