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Beef-Induced Anaphylaxis Confirmed by the Basophil Activation Test

Authors
Kim, JH; Choi, GS; Park, HS; Ye, YM; Kim, JE; An, S
Citation
Allergy, asthma & immunology research, 2(3):206-208, 2010
Journal Title
Allergy, asthma & immunology research
ISSN
2092-73552092-7363
Abstract
Beef allergies are relatively rare, especially in adults. However, clinical manifestations can vary from urticaria, angioedema, anaphylaxis to gastrointestinal symptoms. Currently available tests, such as skin testing or in vitro determination of beef-specific immunoglobulin E (IgE), do not provide an accurate diagnosis of beef allergy. The recent development of the basophil activation test (BAT) presents a new opportunity for the diagnosis of food allergies. Here, we report a 37-year-old woman with a history of recurrent generalised urticaria, nausea, vomiting and hypotension after ingestion of beef, suggesting a beef allergy. Although the skin prick test and serum specific IgE to beef, pork and milk allergens showed negative results using commercial kits, the BAT showed significant upregulation of CD203c in a dose-dependent manner compared to both non-atopic and atopic controls. To our knowledge, this is the first case study of beef allergy consisting of a non-IgE-mediated reaction. The detection of food allergies using direct basophil activation is suggested to complement conventional diagnostic tests.
Keywords
Beef allergybasophil activation testCD203chuman
DOI
10.4168/aair.2010.2.3.206
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
AJOU Authors
김, 주희최, 길순박, 해심예, 영민김, 정은
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