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Combination of nitrous oxide and lidocaine to prevent withdrawal after rocuronium in children

DC Field Value Language
dc.contributor.authorKwak, HJ-
dc.contributor.authorChae, YJ-
dc.contributor.authorLee, SY-
dc.contributor.authorKim, YJ-
dc.contributor.authorKim, JY-
dc.date.accessioned2014-02-19T04:13:14Z-
dc.date.available2014-02-19T04:13:14Z-
dc.date.issued2010-
dc.identifier.issn2005-6419-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/9394-
dc.description.abstractBackground



Pain at the site of rocuronium injection is a common side-effect in pediatric patients. This prospective, randomized, double-blind study evaluated the efficacy of a combination of nitrous oxide and lidocaine pretreatment on withdrawal response during rocuronium injection in children.



Methods



Sixty six pediatric patients, ages 5 to 12 years, were randomly assigned to two groups. The oxygen group received 100% oxygen, and the nitrous oxide group received 50% N2O in oxygen over 2 min. After anesthesia was induced with 2.5% thiopental sodium 5 mg/kg and manual occlusion of the forearm was performed, 1% lidocaine 1 mg/kg was injected over 15 sec. After the occlusion was released, 0.1% rocuronium 0.6 mg/kg was injected over 5 sec. Patient response to rocuronium injection was graded using a 4-point scale.



Results



Overall incidence of withdrawal movements was significantly lower in the nitrous oxide group (1 patients; 3.1%) than in the oxygen group (8 patients; 25.8%) (P = 0.013). No patient in the nitrous oxide group displayed arm or generalized movement (grade 3 or 4) associated with rocuronium injection.



Conclusions



This study demonstrated that a combination of inhaled 50% N2O in O2 and 1 mg/kg lidocaine pretreatment significantly reduced the incidence of rocuronium-induced withdrawal movements in pediatric patients compared with lidocaine pretreatment alone.
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dc.language.isoen-
dc.titleCombination of nitrous oxide and lidocaine to prevent withdrawal after rocuronium in children-
dc.typeArticle-
dc.identifier.urlhttp://ekja.org/search.php?where=aview&id=10.4097/kjae.2010.58.5.446&code=0011KJAE&vmode=FULL-
dc.subject.keywordLidocaine-
dc.subject.keywordNitrous oxide-
dc.subject.keywordRocuronium-
dc.subject.keywordWithdrawal-
dc.contributor.affiliatedAuthor채, 윤정-
dc.contributor.affiliatedAuthor이, 숙영-
dc.contributor.affiliatedAuthor김, 종엽-
dc.type.localJournal Papers-
dc.identifier.doi10.4097/kjae.2010.58.5.446-
dc.citation.titleKorean journal of anesthesiology-
dc.citation.volume58-
dc.citation.number5-
dc.citation.date2010-
dc.citation.startPage446-
dc.citation.endPage449-
dc.identifier.bibliographicCitationKorean journal of anesthesiology, 58(5):446-449, 2010-
dc.identifier.eissn2005-7563-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Anesthesiology & Pain Medicine
Files in This Item:
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