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A case of donor-derived granulocytic sarcoma after allogeneic hematopoietic stem cell transplantation

Authors
Jeong, SH; Han, JH; Jeong, SY; Kang, SY; Lee, HW; Choi, JH; Park, JS
Citation
The Korean journal of hematology, 45(1):70-72, 2010
Journal Title
The Korean journal of hematology
ISSN
1738-79492092-9129
Abstract
The occurrence of granulocytic sarcoma as a pattern of relapse after allogeneic hematopoietic stem cell transplantation (allo-HSCT) is rare. In this paper, we report a rare case of acute myeloid leukemia (AML) relapsed as a granulocytic sarcoma of the donor type. The patient was diagnosed as having AML and underwent an allo-HSCT from his matched sibling donor. Fifty-seven months after allo-HSCT, he developed granulocytic sarcomas of duodenum, jejunum, and left sterno-cleido-mastoid muscle. The bone marrow was normal with 100% donor chimerism. A Y chromosome PCR was performed on the patient’s duodenum specimen as well as bone marrow aspirate in order to check the patient-origin cells. The duodenal specimen was found to contain 41.2% SRY-positive cells (from the donor). Repeat endoscopy on day 2 of chemotherapy showed that the granulocytic sarcoma had shrunk dramatically. The patient died of sepsis during the nadir state 35 days after starting salvage chemotherapy.
Keywords
Granulocytic sarcomaAMLAllo-HSCTDonor type
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pathology
Journal Papers > School of Medicine / Graduate School of Medicine > Medical Genetics
Journal Papers > School of Medicine / Graduate School of Medicine > Hematology-Oncology
AJOU Authors
정, 성현한, 재호정, 선용강, 석윤이, 현우최, 진혁박, 준성
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