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Thyroid Hormonal Changes in Brain Death Donors

Other Title
뇌사 장기 기증자에서 나타나는 갑상선 호르몬 변화
Authors
이, 재명; 이, 영주
Citation
Taehan Chunghwanja Ŭihakhoe chi, 26(3):157-161, 2011
Journal Title
Taehan Chunghwanja Ŭihakhoe chi; Korean journal of critical care medicine; 대한중환자의학회지
ISSN
1229-48022234-3261
Abstract
Background: We analyzed thyroid hormone values in brain death patients to determine the need for thyroid hormone replacement therapy.



Methods: We analyzed 111 brain death donors (77 males and 34 females, mean age, 41.1 years (range; 8 months?72 years) in Ajou University Hospital from 2000 to 2010.



Results: The mean values of thyroid hormones were T3; 72.5 ng/dl (normal range [NR] 60-181 ng/dl), T4; 5.0 ?g/dl (NR 4.5?10.9 ?g/dl), free T4 1.0 ng/dl (NR 0.8-1.5 ng/dl), and TSH 1.5 ?IU/ml (NR 0.35?5.5 ?IU/ml), respectively. However, the values of T4 (correlation coefficient ?0.264, p = 0.005), free T4 (correlation coefficient ?0.305, p = 0.001) and TSH (correlation ?0.206, p = 0.031) significantly decreased based on the increase of interval from the brain death-inducing event to the evaluation time (hereafter, interval). The patients with greater than 8 days of interval (N = 30) showed significantly low thyroid hormone values compared to patients with less than 8 days of interval (N = 81); T3 (70.3 ng/dl vs. 77.0 ng/dl, p = 0.242), T4 (4.7 ng/dl vs. 5.3 ng/dl, p = 0.015), free T4 (0.8 ng/dl vs. 1.2 ng/dl, p = 0.006) and TSH (1.0 ?IU/ml vs. 2.0 ?IU/ml, p = 0.000), respectively.



Conclusions: As the intervals from the brain death-inducing events increased, all thyroid hormone values of brain death donors except T3 significantly decreased. Therefore, we recommend that careful consideration should be given to the interval from brain death-inducing event for the evaluation of thyroid hormone status of brain death patients.
Keywords
brain death donorreplacementthyroid hormone
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Surgery
Journal Papers > School of Medicine / Graduate School of Medicine > Anesthesiology & Pain Medicine
AJOU Authors
이, 재명이, 영주
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