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Effect of a Long-term, Oral Fixed Dose with a Combination of Aledronate and Cacitriol on the Cancellous Bone Microarchitecture in Ovariectomized Rats

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dc.contributor.authorJi, HM-
dc.contributor.authorNair, SG-
dc.contributor.authorWon, YY-
dc.contributor.authorKim, J-
dc.contributor.authorSon, MA-
dc.date.accessioned2014-03-04T03:46:10Z-
dc.date.available2014-03-04T03:46:10Z-
dc.date.issued2011-
dc.identifier.issn1226-8933-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/9573-
dc.description.abstractPurpose: To study the effect of a long-term, oral, fixed dose with a combination of alendronate and calcitriol on the cancellous bone microarchitecture in an ovariectomized rat model.



Materials and Methods: Twenty eight female Sprague-Dawley rats were divided into 2 equal groups: a non-medication group (OVX), and a medication group (ALD). The ALD group was treated with an oral daily fixed dose with a combination of alendronate and calcitriol for six months, starting from 4 weeks after ovariectomy, while the OVX group was given only a placebo. After six months, all animals were sacrificed, and an in vitro micro-CT analysis of the the distal femur was performed. The bone volume fraction (BV/TV), trabecular thickness (Tb.Th), trabecular separation (Tb.Sp), trabecular number (Tb.N), structure model index (SMI), connectivity density (Conn.D), and bone mineral density (BMD) were assessed.



Results: The ALD group had significantly higher BV/TV, Tb N, BMD and Conn.D and it also had significantly lower Tb Sp and SMI than the OVX group.



Conclusion: A long term, daily, oral fixed dose with a combination of alendronate and calcitriol could significantly reduce the osteoporotic changes in this ovariectomized rat model.
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dc.language.isoen-
dc.titleEffect of a Long-term, Oral Fixed Dose with a Combination of Aledronate and Cacitriol on the Cancellous Bone Microarchitecture in Ovariectomized Rats-
dc.title.alternativeAlendronate와 Calcitriol 고정용량복합제의 장기간의 복용이 난소가 제거된 백서의 해면골의 미세구조에 미치는 효과-
dc.typeArticle-
dc.subject.keywordMicroarchitecture-
dc.subject.keywordCancellous bone-
dc.subject.keywordOvariectomized rat-
dc.subject.keywordAlendronate-
dc.subject.keywordCalcitriol-
dc.subject.keywordLong-term-
dc.subject.keywordOral-
dc.subject.keywordCombination-
dc.contributor.affiliatedAuthor지, 형민-
dc.contributor.affiliatedAuthor원, 예연-
dc.type.localJournal Papers-
dc.citation.titleTaehan Chŏnghyŏng Oekwa Yŏn'gu Hakhoe chi-
dc.citation.titleJournal of Korean Orthopaedic Research Society-
dc.citation.title대한정형외과연구학회지-
dc.citation.volume14-
dc.citation.number1-
dc.citation.date2011-
dc.citation.startPage24-
dc.citation.endPage32-
dc.identifier.bibliographicCitationTaehan Chŏnghyŏng Oekwa Yŏn'gu Hakhoe chi, 14(1):24-32, 2011-
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Journal Papers > School of Medicine / Graduate School of Medicine > Orthopedic Surgery
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