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Association between Seasonal Changes in Vitamin D and Bone Mineral Density

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dc.contributor.authorChoi, SH-
dc.contributor.authorLee, DJ-
dc.contributor.authorKim, KM-
dc.contributor.authorKim, BT-
dc.date.accessioned2014-03-04T03:54:26Z-
dc.date.available2014-03-04T03:54:26Z-
dc.date.issued2011-
dc.identifier.issn1226-8704-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/9574-
dc.description.abstract연구목적:비타민 D 결핍은 이차성 부갑상선 기능항진증을 유발하여 골밀도의 감소를 가져온다. 비타민 D는 자외선에 의해 피부에서 합성되므로 일조량에 따라 계절별로 혈중농도가 달라진다. 이 연구는 어느 계절에 측정된 혈청 25-hydroxy 비타민 D 값이 실제 골밀도와 연관이 있는지 알아보았다.



연구 재료 및 방법:이 연구는 1999년 1월부터 2005년 3월까지 아주대학병원 건강검진센터를 내원한 여성 중 혈청 25-hydroxy 비타민 D와 골밀도를 측정한, 2,878명을 대상으로 하였다.



결과: 혈청 25-hydroxy 비타민 D 농도는 봄, 겨울에 비해 여름, 가을에 통계적으로 의미 있게 높았다. 그러나 겨울과 봄 사이 또는 여름과 가을 사이는 혈청 25-hydroxy 비타민 D 농도에 차이가 없었다. 혈청 25-hydroxy 비타민 D 농도는 골밀도에 따른 골다공증 분류와 연관성이 없었다.



결론: 혈청 25-hydroxy 비타민 D 농도는 검사 당시 비타민 D 상태는 반영하지만, 이것이 장기적으로 골밀도와 어떤 관련이 있는 지는 분명하지 않으므로 골다공증 진료에서 혈청 25-hydroxy 비타민 D 농도를 이용할 때는 주의가 필요하다.
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dc.description.abstractObjectives:Vitamin D deficiency, which causes secondary hyperparathyroidism, is considered to be a major contributor to osteoporosis. Because the serum 25-hydroxyvitamin D (25-OHD) level depend on sun exposure and, varies by season, the level of serum 25-OHD in each season at which vitamin D status can lead to changes in bone mineral density (BMD) is not known.



Methods:A total of 2,878 women who underwent periodic health examinations at Ajou University Hospital were included in this study. We measured the serum 25-OHD concentrations using radioimmunoassay and BMDs using dual energy x-ray absorptiometry (DXA). The differences in serum 25-OHD levels among groups as a function of age, season, and BMD were tested by one-way ANOVA.



Results: The serum 25-OHD level was not different based on age, but by season, with higher levels in the summer and autumn than in the winter and spring. However, the 25-OHD level did not have a significant relationship with BMD in any season.



Conclusion:The serum 25-OHD level represents vitamin D status at the time of testing, which is not associated with long-term changes in BMD. When the 25-OHD levels are used to make clinical decisions related to the treatment of osteoporosis, careful interpretation is required.
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dc.language.isoen-
dc.titleAssociation between Seasonal Changes in Vitamin D and Bone Mineral Density-
dc.typeArticle-
dc.subject.keyword비타민 D-
dc.subject.keyword골밀도-
dc.subject.keyword계절변화-
dc.subject.keywordBone mineral density-
dc.subject.keywordSeasonal variation-
dc.subject.keywordVitamin D-
dc.contributor.affiliatedAuthor이, 득주-
dc.contributor.affiliatedAuthor김, 광민-
dc.contributor.affiliatedAuthor김, 범택-
dc.type.localJournal Papers-
dc.citation.titleJournal of the Korean Society of Menopause-
dc.citation.volume17-
dc.citation.number2-
dc.citation.date2011-
dc.citation.startPage88-
dc.citation.endPage93-
dc.identifier.bibliographicCitationJournal of the Korean Society of Menopause, 17(2). : 88-93, 2011-
dc.relation.journalidJ012268704-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Family Practice & Community Health
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