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Comparison of effect-site concentration of remifentanil for tracheal intubation with the lightwand and laryngoscopy during propofol target-controlled infusion

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dc.contributor.authorKim, JS-
dc.contributor.authorKim, DH-
dc.contributor.authorMin, SK-
dc.contributor.authorKim, KM-
dc.contributor.authorKim, JY-
dc.date.accessioned2014-03-06-
dc.date.available2014-03-06-
dc.date.issued2011-
dc.identifier.issn2005-6419-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/9591-
dc.description.abstractBackground: Target-controlled infusion (TCI) of propofol and remifentanil can provide satisfactory intubating conditions without a neuromuscular blocking agent. We compared the effect-site concentration of remifentanil required for intubation with the lightwand and the Macintosh laryngoscope during propofol TCI without a neuromuscular blocking agent in adult patients.



Methods: Forty-nine patients were randomly assigned to the lightwand group (n = 25) or the direct laryngoscope group (n = 24). Anesthesia was induced by propofol TCI with an effect-site concentration of 5.4 μg/ml. Two minutes after start of propofol TCI, remifentanil was administered at the predetermined effect-site concentration. The effect-site concentration of remifentanil was determined using Dixon’s up-and-down method (0.5 ng/ml as a step size). The first patient in each group was tested at 4.5 ng/ml of remifentanil. Tracheal intubation was performed 2 min after the start of remifentanil TCI. Acceptable intubation was defined as an excellent or good intubating conditions.



Results: Using a modified Dixon’s up and down method, the EC50 ± SD of remifentanil in the lightwand and laryngoscope groups was 4.75 ± 0.71 ng/ml and 5.08 ± 0.52 ng/ml, respectively; there was no statistically significant difference between the groups (P = 0.373).



Conclusions: The effect-site concentration of remifentanil for acceptable intubation with the lightwand and Macintosh laryngoscope in 50% of adults did not differ during propofol TCI without a neuromuscular blocking agent.
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dc.language.isoen-
dc.titleComparison of effect-site concentration of remifentanil for tracheal intubation with the lightwand and laryngoscopy during propofol target-controlled infusion-
dc.typeArticle-
dc.identifier.urlhttp://ekja.org/search.php?where=aview&id=10.4097/kjae.2011.60.6.393&code=0011KJAE&vmode=FULL-
dc.subject.keywordIntubation-
dc.subject.keywordLightwand-
dc.subject.keywordPropofol-
dc.subject.keywordRemifentanil-
dc.subject.keywordTarget-controlled infusion-
dc.contributor.affiliatedAuthor김, 진수-
dc.contributor.affiliatedAuthor김, 대희-
dc.contributor.affiliatedAuthor민, 상기-
dc.contributor.affiliatedAuthor김, 종엽-
dc.type.localJournal Papers-
dc.identifier.doi10.4097/kjae.2011.60.6.393-
dc.citation.titleKorean journal of anesthesiology-
dc.citation.volume60-
dc.citation.number6-
dc.citation.date2011-
dc.citation.startPage393-
dc.citation.endPage397-
dc.identifier.bibliographicCitationKorean journal of anesthesiology, 60(6):393-397, 2011-
dc.identifier.eissn2005-7563-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Anesthesiology & Pain Medicine
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