Relation Between Fluorodeoxyglucose Uptake and Glucose Transporter-1 Expression in Gastric Signet Ring Cell Carcinoma
Choi, BH; Song, HS; An, YS; Han, SU; Kim, JH; Yoon, JK
Nuclear medicine and molecular imaging, 45(1):30-35, 2011
Nuclear medicine and molecular imaging
Purpose: Gastric signet ring cell carcinoma (GSRC) is known to have low fluorodeoxyglucose (FDG) uptake.
The aim of the study was to investigate the relation between FDG uptake and glucose transporter (GLUT)-1 expression and clinicopathologic parameters in cases of GSRC.
Materials and Methods: Forty patients (28 men, mean age 54±12 years) with histologically confirmed GSRC who underwent pre-operative [18F]FDG PET/CT were enrolled. Maximum standardized uptake values (SUVmax) were compared with clinicopathologic parameters and GLUT-1 expression. Cases were divided based on GLUT-1 expression in tumor tissues into a membranous group (n=17) and a cytoplasmic group (n=23).
Results: Mean SUVmax was significantly higher in the membranous group than in the cytoplasmic group (6.06±2.79 vs. 3.67±1.54, P=0.03). Gastric wall invasion, depth of invasion, extent of LN metastasis, overall stage, and tumor size were found to be related to SUVmax. On the other hand, age, sex, and the presence of distant metastasis were not related to SUVmax. Multivariate analysis revealed that membranous GLUT-1 expression and the extent of LN metastasis independently predicted high FDG uptake.
Conclusions: This study demonstrates that high FDG uptake is mediated by membranous GLUT-1 expression in GSRC.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
Total Visit :3,088,484
Total Download :1,260,411
Today View :1,647
Ajou University Medical Information & Media Center 164 Worldcup-ro Yeongtong-gu Suwon 16499 Korea / TEL : 031-219-5312 / FAX : 031-219-5314 Copyright (c) Ajou University Medical Information & Media Center All Rights Reserved. AJOU Open Repository는 국립중앙도서관 OAK 보급사업으로 구축되었습니다.