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Clinical Significance of Diffuse 18F-FDG Uptake in Residual Thyroid Gland after Unilateral Thyroid Lobectomy

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dc.contributor.authorSong, HS-
dc.contributor.authorLee, SJ-
dc.contributor.authorYoon, SH-
dc.contributor.authorLee, J-
dc.contributor.authorSoh, EY-
dc.contributor.authorAn, YS-
dc.contributor.authorYoon, JK-
dc.description.abstractPurpose: We investigated the clinical significance of diffuse uptake in remaining thyroid after unilateral lobectomy for thyroid cancer.

Methods: A total of 144 thyroid cancer patients who underwent 18F-FDG PET/CT after lobectomy were enrolled in the present study. The PET/CT images were evaluated for the presence of diffuse 18F-FDG uptake with maximum SUV (SUVmax) >2.0 in the residual thyroid and placed into one of two groups: with diffuse uptake and without diffuse uptake group. Clinical, laboratory, and PET/CT parameters in both groups were compared. Correlations between SUVmax of thyroid and available parameters were analyzed.

Results Forty-two of 144 patients (29.2%) had diffuse thyroid uptake (mean SUVmax: 3.2±1.1). All patients with diffuse uptake and 96 (94.1%) without diffuse uptake were receiving thyroxine therapy (P=0.09). Thyroid function tests showed that most patients were euthyroid status (78.6 vs. 85.3%, P=0.36). TgAb levels were significantly higher in patients with diffuse uptake (338.0±664.6 vs. 57.3±46.4, P<0.0001). Mean attenuation values in the diffuse uptake group were significantly lower (72.2±15. vs. 97.0±16.0, P<0.0001). An inverse correlation was found between SUVmax and mean attenuation values of residual thyroid in all patients (r=−0.57, P<0.0001) and subgroup with diffuse uptake (r=−0.31, P<0.05).

Conclusion: In this study, diffuse 18F-FDG uptake in the residual thyroid after unilateral lobectomy was a relatively frequent finding and may be associated with chronic thyroiditis. This uptake is not influenced by thyroid status or thyroxine therapy. The 18F-FDG uptake is inversely correlated with mean attenuation value of thyroid.
dc.titleClinical Significance of Diffuse 18F-FDG Uptake in Residual Thyroid Gland after Unilateral Thyroid Lobectomy-
dc.subject.keywordDiffuse thyroid uptake-
dc.subject.keywordFDG PET/CT-
dc.subject.keywordThyroid lobectomy-
dc.contributor.affiliatedAuthor이, 수진-
dc.contributor.affiliatedAuthor소, 의영-
dc.contributor.affiliatedAuthor안, 영실-
dc.contributor.affiliatedAuthor윤, 준기-
dc.type.localJournal Papers-
dc.citation.titleNuclear medicine and molecular imaging-
dc.identifier.bibliographicCitationNuclear medicine and molecular imaging, 45(3):197-202, 2011-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Surgery
Journal Papers > School of Medicine / Graduate School of Medicine > Nuclear Medicine & Molecular Imaging
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