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Efficacy and Safety of Paliperidone Extended Release in Schizophrenia Patients Requiring a Switch in Antipsychotic Medication by Switching Previous Antipsychotics to Paliperidone Extended Release

Other Title
약물 교체가 필요한 조현병 환자에서 Paliperidone Extended Release로의 교체 후 유효성과 안전성에 관한 분석
Authors
문, 영선; 나, 경세; 김, 철응; 김, 용식; 윤, 진상; 안, 용민; 정, 희연; 유, 범희; 전, 양환; 이, 상규; 석, 정호; 함, 병주; 박, 두병; 김, 현; 이, 병욱; 홍, 창형; 김, 종우; 한, 진희
Citation
Taehan Chŏngsin Yangmul Hakhoe chi, 23(3):97-106, 2012
Journal Title
Taehan Chŏngsin Yangmul Hakhoe chi; The Korean journal of psychopharmacology; 대한정신약물학회지
ISSN
1017-57172092-5700
Abstract
Objective: This study aimed to evaluate the clinical efficacy, safety, and tolerability of paliperidone extended release (ER) in patients with schizophrenia by switching previous antipsychotics to paliperidone ER. <br> <br> <br> <br>Methods: An open-label, 24 weeks, prospective, non-comparative, multi-center study evaluated total 387 patients with schizophrenia requiring a switch in antipsychotic medication due to suboptimal efficacy, intolerability, and non-compliance. Patients were switched to flexible-dose trial of paliperidone ER (3-12 mg/day). Efficacy was measured by Krawiecka Scale, Clinical Global Impression-Schizophrenia-Severity (CGI-SCH-S), Clinical Global Impression-Schizophrenia-Improvement (CGI-SCH-I), sleep visual analog scale (VAS), and Personal and Social Performance Scale (PSP). Safety assessments included adverse events (AEs), evaluation of extrapyramidal symptoms (EPS) using the Drug Induced Extrapyramidal Symptoms Scale (DIEPSS), and laboratory tests. <br> <br> <br> <br>Results: Data from a total of 321 subjects who took the paliperidone ER and had at least one follow-up assessment without a major protocol violation were analyzed. Switching to paliperidone ER led to a significant improvement in the Krawiecka, CGI-SCH-S, CGI-SCH-I, PSP, and DIEPSS scales. However, serum prolactin levels and metabolic parameters including body weight and waist circumference were significantly increased. Insomnia was the most common adverse event. <br> <br> <br> <br>Conclusion: This study suggested that patients with schizophrenia who showed insufficient response or intolerance to other previous antipsychotics can be switched to paliperidone ER, with efficacy, safety, and tolerability.
Keywords
조현병비정형 항정신병 약물Paliperidone ER효과내약성SchizophreniaAtypical antipsychoticEfficacyTolerability
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Psychiatry & Behavioural Sciences
AJOU Authors
홍, 창형
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