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The Role of C-Kit Receptor Level as a Serological Marker for Predicting the Extent of Upper and Lower Airway Inflammation in Patients Sensitized to House Dust Mites

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dc.contributor.author유, 혜수-
dc.contributor.author김, 주희-
dc.contributor.author황, 의경-
dc.contributor.author남, 영희-
dc.contributor.author진, 현정-
dc.contributor.author신, 유섭-
dc.contributor.author예, 영민-
dc.contributor.author남, 동호-
dc.contributor.author박, 해심-
dc.date.accessioned2014-03-11T04:42:51Z-
dc.date.available2014-03-11T04:42:51Z-
dc.date.issued2012-
dc.identifier.issn1226-8739-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/9699-
dc.description.abstractBackground: Allergic rhinitis can progress to asthma. Both allergic rhinitis and asthma are characterized by Th2-dependent inflammation due to activated mast cells and eosinophils. Mast cells are dependent on kit-mediated activation, and the stem cell factor (SCF)/c-kit pathway leads to eosinophil infiltration. We investigated whether inflammation through the SCF/c-kit pathway would be associated with upper and lower airway inflammation.
Methods: We enrolled 71 allergic asthma patients with rhinitis (group I) and 47 patients with allergic rhinitis alone (group II), and 59 non-atopic healthy controls (group III). Groups I and II showed positive responses to house dust mites in skin prick tests. The serum concentrations of c-kit receptor and SCF were measured by using ELISA. Eosinophil cationic protein (ECP) levels were measured by using the CAP system. Other clinical parameters were analyzed.
Results: There were significant differences in the mean values of c-kit receptor levels between the 3 groups (117.27± 41.05 vs. 93.13±37.21 vs. 88.45±24.32 ng/mL, P<0.001). The c-kit receptor level was the highest in group I. However, no significant differences were found in SCF levels between the 3 groups. A positive correlation was found between c-kit receptor and ECP levels in groups I and II (r=0.31, P=0.016). Moreover, a positive correlation was found between c-kit receptor levels and total eosinophil counts in groups I and II (r=0.34, P<0.001). However, there were no significant associations between c-kit receptor levels and clinical parameters, such as forced expiratory volume 1% predicted value in group I.
Conclusion: Serum c-kit receptor levels can be a useful serologic marker for predicting the extent of eosinophilic inflammation in upper and lower airway inflammation.
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dc.formatapplication/pdf-
dc.language.isoko-
dc.titleThe Role of C-Kit Receptor Level as a Serological Marker for Predicting the Extent of Upper and Lower Airway Inflammation in Patients Sensitized to House Dust Mites-
dc.title.alternative집먼지진드기에 감작된 알레르기성 천식과 비염 환자에서 기도 염증 정도의 예측 인자로서의 혈청 c-kit 수용체의 역할-
dc.typeArticle-
dc.subject.keywordProto-oncogene protein c kit-
dc.subject.keywordAsthma-
dc.subject.keywordRhinitis-
dc.contributor.affiliatedAuthor유, 혜수-
dc.contributor.affiliatedAuthor신, 유섭-
dc.contributor.affiliatedAuthor예, 영민-
dc.contributor.affiliatedAuthor남, 동호-
dc.contributor.affiliatedAuthor박, 해심-
dc.type.localJournal Papers-
dc.citation.titleKorean journal of asthma, allergy and clinical immunology-
dc.citation.volume32-
dc.citation.number2-
dc.citation.date2012-
dc.citation.startPage92-
dc.citation.endPage100-
dc.identifier.bibliographicCitationKorean journal of asthma, allergy and clinical immunology, 32(2). : 92-100, 2012-
dc.relation.journalidJ112268739-
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Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
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