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Diffuse Large B Cell Lymphoma Associated with Epstein-Barr Virus Infection in a Liver Transplanted Child

Other Title
간이식 환자에서 발생한 Epstein-Barr 바이러스 관련 미만성거대B세포림프종 1예
Authors
한, 승헌; 정, 현주; 박, 준은; 한, 재호
Citation
Clinical pediatric hematology-oncology, 19(2):114-117, 2012
Journal Title
Clinical pediatric hematology-oncology
ISSN
2233-52502233-4580
Abstract
We report a case of 13 years old male patient. He was diagnosed as glycogen storage disease Ib at 6 month age, and received cadaver donor liver transplantation at 2 years and 4 months. He underwent immunosuppression for 9 years with several im-munosuppressants including tacrolimus. Then he visited hospital for gum swelling and showed multiple malignancy suspicious lesions at nasal cavity, maxilla, mandibula, fron-tal bone, temporal bone, C1 and C2 spines, and several submandibular lymph nodes at radiologic study. Biopsy was done at oral cavity lesion, and histologically diagnosed as diffuse large B-cell lymphoma. The tissue specimen showed positivity in Epstein-Barr virus polymerase chain reaction (PCR). After diagnosis, the patient stopped all im-munosuppressive agents and received 9 cycles of CHOP (cyclophosphamide, adriamy-cin, vincristine and prenisolone) chemotherapy for 8 months, then the patient achieved radiologic remission state, and being well without any signs of recurrence for two years of follow up.
Keywords
Epstein-Barr virusLymphomaLarge B-cellDiffuseLiver transplantation
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pathology
Journal Papers > School of Medicine / Graduate School of Medicine > Pediatrics & Adolescent Medicine
AJOU Authors
정, 현주박, 준은한, 재호
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