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Is it Acceptable to Select Antibiotics for the Treatment of Community-acquired Acute Cystitis Based on the Antibiotics Susceptibility Results for Uropathogens from Community-acquired Acute Pyelonephritis in Korea?

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dc.contributor.author김, 봉영-
dc.contributor.author김, 지은-
dc.contributor.author위, 성헌-
dc.contributor.author박, 선희-
dc.contributor.author조, 용균-
dc.contributor.author임, 승관-
dc.contributor.author신, 상엽-
dc.contributor.author염, 준섭-
dc.contributor.author이, 진서-
dc.contributor.author권, 기태-
dc.contributor.author이, 혁-
dc.contributor.author정, 희진-
dc.contributor.author박, 대원-
dc.contributor.author류, 성열-
dc.contributor.author정, 문현-
dc.contributor.author배, 현주-
dc.date.accessioned2014-03-14T04:23:50Z-
dc.date.available2014-03-14T04:23:50Z-
dc.date.issued2012-
dc.identifier.issn2093-2340-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/9730-
dc.description.abstractBackground: Uncomplicated acute cystitis (CA-UAC) is one of the most common infections treated with antibiotics in the community. However, few data on etiology of CA-UAC and its susceptibility to antibiotics are available, primarily because, in Korea, insurance does not allow reimbursement for microbiological evaluation of CA-UAC. However, microbiologic data on community-acquired uncomplicated acute pyelonephritis (CA-UAPN) are available. The objective of the study was to evaluate the question of whether microbiologic data on CA-UAPN can be used for treatment of CA-UAC; therefore, etiology and antimicrobial susceptibility were compared between pathogens of CA-UAC and those of CA-UAPN.



Materials and Methods : During 2008, 538 CA-UACs and 1,265 CA-UAPNs were recruited retrospectively from 14 hospitals (UTI research group). Microbiologic data on etiology and susceptibility to antibiotics were collected retrospectively.



Results: Urine culture was positive in 131 CA-UACs (131/469, 27.9%) and 719 CA-UAPNs (719/1249, 57.6%). Escherichia coli was the most common pathogen in both groups [83.2% (109/131) in CA-UAC vs. 91.9% (661/719) in CA-UAPN]. Susceptibility to common UTI regimens, such as ciprofloxacin, extended-spectrum cephalosporins, and trimethoprim/sulfamethoxazole did not differ between urinary pathogens of CA-UACs and CA-UAPNs, however, a significant difference was observed in rates of resistance to ampicillin/sulbactam (16.5% vs. 42.9%, P<0.001, respectively).



Conclusions:Conclusions: Rates of resistance of E. coli from CA-UAC and CA-UAPN to most antibiotics did not differ. For proper treatment, further microbiological evaluation for CA-UAC is mandatory.
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dc.language.isoko-
dc.titleIs it Acceptable to Select Antibiotics for the Treatment of Community-acquired Acute Cystitis Based on the Antibiotics Susceptibility Results for Uropathogens from Community-acquired Acute Pyelonephritis in Korea?-
dc.title.alternative국내에서 지역사회 급성 신우신염 원인균의 항균제 감수성 결과에 근거하여 지역사회 급성 방광염 치료 항균제를 선택할 수 있는가?-
dc.typeArticle-
dc.identifier.urlhttp://www.icjournal.org/search.php?where=aview&id=10.3947/ic.2012.44.4.269&code=0086IC&vmode=FULL-
dc.subject.keywordCystitis-
dc.subject.keywordPyelonephritis-
dc.subject.keywordAntibiotic-
dc.subject.keywordResistance-
dc.subject.keywordCommunity-
dc.contributor.affiliatedAuthor임, 승관-
dc.type.localJournal Papers-
dc.identifier.doi10.3947/ic.2012.44.4.269-
dc.citation.titleInfection & chemotherapy-
dc.citation.volume44-
dc.citation.number4-
dc.citation.date2012-
dc.citation.startPage269-
dc.citation.endPage274-
dc.identifier.bibliographicCitationInfection & chemotherapy, 44(4):269-274, 2012-
dc.identifier.eissn2092-6448-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Infectious Diseases
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