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B Cell Targeted Therapy in Rheumatic Disease

Other Title
류마티스질환에서 B 세포 표적 치료
Authors
서, 창희
Citation
Journal of rheumatic diseases, 19(2):67-72, 2012
Journal Title
Journal of rheumatic diseases; 대한류마티스학회지
ISSN
2093-940X2233-4718
Abstract
B cells play an important role in the pathogenesis of autoimmune disease. B cells not only produce pathogenic autoantibodies, but also present self-antigens to T cells and provide costimulatory signals for self-reactiveT cells. Recently, biologics have been tried in several autoimmune diseases as immune modulators with some promising results. Among them, several biologic agents that target B cells have led to improved patients’ outcomes and quality of life in patients with rheumatoid arthritis and systemic lupus erythematosus. These agents either deplete B cells by targeting B cell surface antigens, such as CD20 and CD22, or block B cell survival by inhibiting the activity of B cell survival factors, such as BLyS and APRIL. Initially, I discuss briefly the role of B cells in driving autoimmune diseases, and then focus on the efficacy and safety data of the B cell-targeted therapy in rheumatoid arthritis and systemic lupus erythematosus.
Keywords
B cellTargetTreatmentRheumatoid arthritisLupus
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Rheumatology
AJOU Authors
서, 창희
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