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Guillain-Barre Syndrome, Antiphospholipid Syndrome and Lupus Nephritis as Initial Manifestation of Systemic Lupus Erythematosus

Other Title
Guillain-Barre 증후군과 항인지질 증후군, 루푸스 신염으로 발현된 전신홍반루푸스
Authors
정, 주양; 김, 현아; 주, 인수; 원, 제환; 고, 보람; 박, 진주; 곽, 지영; 최, 용우; 김, 동훈; 서, 창희
Citation
Journal of rheumatic diseases, 19(5):274-279, 2012
Journal Title
Journal of rheumatic diseases; 대한류마티스학회지
ISSN
2093-940X2233-4718
Abstract
Systemic lupus erythematosus (SLE) is an autoimmune disease with various manifestations, while its autoantibodies and immune reactions involve multiple organs. Neuropsychiatric involvement in SLE is known to be common, however, peripheral neuropathy is relatively rare. Guillain-Barre syndrome is clinically defined as an acute demyelinating peripheral neuropathy causing weakness and numbness in the legs and arms. We describe a case of Guillain-Barre syndrome with antiphospholipid syndrome and lupus nephritis. The patient was admitted with fever and diarrhea. He developed progressive weakness of the upper and lower extremities and dysarthria with characteristic nerve conduction patterns compatible with Guillain-Barre syndrome. He also had proteinuria and gangrene of the hand and toe with antiphospholipid antibody. He received intravenous immunoglobulin and plasmapheresis for progressive neuropathy, intravenous high dose steroid to control activity of SLE, and anticoagulation for antiphospholipid syndrome. Neuropsychiatric manifestation of SLE is related to lupus activity closely, so it is important to control lupus activity.
Keywords
Neuropsychiatric lupusGuillain-Barre syndromeLupus nephritisAntiphospholipid syndrome
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Neurology
Journal Papers > School of Medicine / Graduate School of Medicine > Radiology
Journal Papers > School of Medicine / Graduate School of Medicine > Cardiology
Journal Papers > School of Medicine / Graduate School of Medicine > Rheumatology
AJOU Authors
정, 주양김, 현아주, 인수원, 제환최, 용우서, 창희
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