Transformation of Recurred Lupus Nephritis from Class IV to Class V
재발된 루푸스 신장염에서 증식성 병변에서 비증식성 병변으로의 전환 1예
박, 진주; 곽, 지영; 정, 주양; 고, 보람; 김, 현아; 서, 창희
Journal of rheumatic diseases, 19(5):290-294, 2012
Journal of rheumatic diseases; 대한류마티스학회지
There are numerous studies about the transformation of renal pathology during lupus nephritis progression. A number of researchers suggest that patients with previous proliferative glomerulonephritis may not need to repeat renal biopsy in relation to treatment strategies. However, the pathology of renal biopsy could offer important information to clinicians about the progression of disease. Here, we report a rare case of the convertion of ISN/RPS classification from a proliferative lesion to a wholly non- proliferative lesion. A 40-year-old female was admitted complaining of generalized edema for 1 month. At the age of 33 she had been diagnosed as SLE with proliferative lupus nephritis. The renal remission was induced with corticosteroid pulse therapy and 12 cycles of intravenous cyclophosphamide treatment. The repeated renal biopsy revealed class V lupus nephritis compared with referential biopsy of class IV-G. A better prognosis is expected with lower activity and a lower chronicity index. Repeat renal biopsy may give useful information relating to the prognosis of nephritis.
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