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Patient-specific orthotopic glioblastoma xenograft models recapitulate the histopathology and biology of human glioblastomas in situ.

Authors
Joo, KM; Kim, J; Jin, J; Kim, M; Seol, HJ; Muradov, J; Yang, H; Choi, YL; Park, WY; Kong, DS; Lee, JI; Ko, YH; Woo, HG; Lee, J; Kim, S; Nam, DH
Citation
Cell reports, 3(1):260-273, 2013
Journal Title
Cell reports
ISSN
2211-1247
Abstract
Frequent discrepancies between preclinical and clinical results of anticancer agents demand a reliable translational platform that can precisely recapitulate the biology of human cancers. Another critical unmet need is the ability to predict therapeutic responses for individual patients. Toward this goal, we have established a library of orthotopic glioblastoma (GBM) xenograft models using surgical samples of GBM patients. These patient-specific GBM xenograft tumors recapitulate histopathological properties and maintain genomic characteristics of parental GBMs in situ. Furthermore, in vivo irradiation, chemotherapy, and targeted therapy of these xenograft tumors mimic the treatment response of parental GBMs. We also found that establishment of orthotopic xenograft models portends poor prognosis of GBM patients and identified the gene signatures and pathways signatures associated with the clinical aggressiveness of GBMs. Together, the patient-specific orthotopic GBM xenograft library represent the preclinically and clinically valuable "patient tumor's phenocopy" that represents molecular and functional heterogeneity of GBMs.
MeSH terms
AdultAgedAnimalsBrain Neoplasms/drug therapy/*pathology/radiotherapy/surgeryCell ShapeCell Transformation, Neoplastic/pathologyFemaleGenome, Human/geneticsGlioblastoma/drug therapy/*pathology/radiotherapy/surgeryHumansMagnetic Resonance ImagingMaleMiceMiddle AgedMolecular Targeted TherapyNeoplasm InvasivenessSpheroids, Cellular/pathologyTreatment Outcome*Xenograft Model Antitumor AssaysYoung Adult
DOI
10.1016/j.celrep.2012.12.013
PMID
23333277
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Physiology
AJOU Authors
우, 현구
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