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MTERF3 regulates mitochondrial ribosome biogenesis in invertebrates and mammals.

Authors
Wredenberg, A; Lagouge, M; Bratic, A; Metodiev, MD; Spåhr, H; Mourier, A; Freyer, C; Ruzzenente, B; Tain, L; Grönke, S; Baggio, F; Kukat, C; Kremmer, E; Wibom, R; Polosa, PL; Habermann, B; Partridge, L; Park, CB; Larsson, NG
Citation
PLoS genetics, 9(1):e1003178-e1003178, 2013
Journal Title
PLoS genetics
ISSN
1553-73901553-7404
Abstract
Regulation of mitochondrial DNA (mtDNA) expression is critical for the control of oxidative phosphorylation in response to physiological demand, and this regulation is often impaired in disease and aging. We have previously shown that mitochondrial transcription termination factor 3 (MTERF3) is a key regulator that represses mtDNA transcription in the mouse, but its molecular mode of action has remained elusive. Based on the hypothesis that key regulatory mechanisms for mtDNA expression are conserved in metazoans, we analyzed Mterf3 knockout and knockdown flies. We demonstrate here that decreased expression of MTERF3 not only leads to activation of mtDNA transcription, but also impairs assembly of the large mitochondrial ribosomal subunit. This novel function of MTERF3 in mitochondrial ribosomal biogenesis is conserved in the mouse, thus we identify a novel and unexpected role for MTERF3 in coordinating the crosstalk between transcription and translation for the regulation of mammalian mtDNA gene expression.
MeSH terms
AnimalsDNA, Mitochondrial/genetics*Drosophila Proteins/geneticsDrosophila melanogaster/*geneticsGene Expression RegulationInvertebrates/genetics/metabolismMice*Mitochondria/genetics/metabolism*Mitochondrial Proteins/geneticsOxidative Phosphorylation*Ribosomes/genetics/metabolismTranscription, Genetic
DOI
10.1371/journal.pgen.1003178
PMID
23300484
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Physiology
AJOU Authors
박, 찬배
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