112 329

Cited 16 times in

The immune-stimulating peptide WKYMVm has therapeutic effects against ulcerative colitis.

Authors
Kim, SD; Kwon, S; Lee, SK; Kook, M; Lee, HY; Song, KD; Lee, HK; Baek, SH; Park, CB; Bae, YS
Citation
Experimental & molecular medicine, 45:e40-e40, 2013
Journal Title
Experimental & molecular medicine
ISSN
1226-36132092-6413
Abstract
In this study, we examined the therapeutic effects of an immune-stimulating peptide, WKYMVm, in ulcerative colitis. The administration of WKYMVm to dextran sodium sulfate (DSS)-treated mice reversed decreases in body weight, bleeding score and stool score in addition to reversing DSS-induced mucosa destruction and shortened colon. The WKYMVm-induced therapeutic effect against ulcerative colitis was strongly inhibited by a formyl peptide receptor (FPR) 2 antagonist, WRWWWW, indicating the crucial role of FPR2 in this effect. Mechanistically, WKYMVm effectively decreases intestinal permeability by stimulating colon epithelial cell proliferation. WKYMVm also strongly decreases interleukin-23 and transforming growth factor-β production in the colon of DSS-treated mice. We suggest that the potent immune-modulating peptide WKYMVm and its receptor FPR2 may be useful in the development of efficient therapeutic agents against chronic intestinal inflammatory diseases.
MeSH terms
Adjuvants, Immunologic/pharmacology/*therapeutic useAnimalsCaco-2 CellsCell ProliferationColitis, Ulcerative/*drug therapy/metabolismColon/pathologyHumansInterleukin-23/genetics/metabolismIntestinal Mucosa/drug effects/metabolism/pathologyMiceMice, Inbred C57BLOligopeptides/pharmacology/*therapeutic usePermeabilityReceptors, Formyl Peptide/antagonists & inhibitorsTransforming Growth Factor beta/genetics/metabolism
DOI
10.1038/emm.2013.77
PMID
24030327
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Physiology
AJOU Authors
박, 찬배
Full Text Link
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse