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TIS21(/BTG2/PC3) inhibits interleukin-6 expression via downregulation of STAT3 pathway.

Authors
Quy, LN; Choi, YW; Kim, YH; Chwae, YJ; Park, TJ; Lim, IK
Citation
Cellular signalling, 25(12):2391-2399, 2013
Journal Title
Cellular signalling
ISSN
0898-65681873-3913
Abstract
Cancer cell growth was increased when co-cultured with fibroblasts, however, no effect was observed when co-cultured with TIS21-overexpressed fibroblast. Therefore, the role of TIS21 played in cancer microenvironment was investigated. TIS21 decreased interleukin-6 (IL-6) expression in human dermal fibroblast (HDF). Adenoviral transduction of TIS21 gene to HDF decreased the secretion of IL-6, whereas knockdown of the gene increased IL-6 expression. Furthermore, TIS21 overexpression inhibited STAT3 binding to IL-6 promoter region as well as JAK2-STAT3 signaling by inhibiting reactive oxygen species (ROS) generation by being localized in mitochondria. Mitochondria-target TIS21 (MT-TIS21) also inhibited IL-6 expression by downregulating STAT3 phosphorylation, whereas NF-κB pathway was not influenced by TIS21 expression. These results indicate that TIS21 negatively regulated cancer cell growth by inhibiting IL-6 expression through downregulation of STAT3 activation.
Keywords
Interleukin-6JAK2ROSSTAT3TIS21(/BTG2/PC3)
DOI
10.1016/j.cellsig.2013.07.024
PMID
23917204
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Microbiology
Journal Papers > School of Medicine / Graduate School of Medicine > Biochemistry & Molecular Biology
AJOU Authors
최, 용준박, 태준임, 인경
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