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Cited 64 times in

Cornichon proteins determine the subunit composition of synaptic AMPA receptors.

DC Field Value Language
dc.contributor.authorHerring, BE-
dc.contributor.authorShi, Y-
dc.contributor.authorSuh, YH-
dc.contributor.authorZheng, CY-
dc.contributor.authorBlankenship, SM-
dc.contributor.authorRoche, KW-
dc.contributor.authorNicoll, RA-
dc.date.accessioned2014-04-30T04:13:01Z-
dc.date.available2014-04-30T04:13:01Z-
dc.date.issued2013-
dc.identifier.issn0896-6273-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/9870-
dc.description.abstractCornichon-2 and cornichon-3 (CNIH-2/-3) are AMPA receptor (AMPAR) binding proteins that promote receptor trafficking and markedly slow AMPAR deactivation in heterologous cells, but their role in neurons is unclear. Using CNIH-2 and CNIH-3 conditional knockout mice, we find a profound reduction of AMPAR synaptic transmission in the hippocampus. This deficit is due to the selective loss of surface GluA1-containing AMPARs (GluA1A2 heteromers), leaving a small residual pool of synaptic GluA2A3 heteromers. The kinetics of AMPARs in neurons lacking CNIH-2/-3 are faster than those in WT neurons due to the fast kinetics of GluA2A3 heteromers. The remarkably selective effect of CNIHs on the GluA1 subunit is probably mediated by TARP γ-8, which prevents a functional association of CNIHs with non-GluA1 subunits. These results point to a sophisticated interplay between CNIHs and γ-8 that dictates subunit-specific AMPAR trafficking and the strength and kinetics of synaptic AMPAR-mediated transmission.-
dc.language.isoen-
dc.subject.MESHAnimals-
dc.subject.MESHAnimals, Newborn-
dc.subject.MESHCells, Cultured-
dc.subject.MESHExcitatory Postsynaptic Potentials/*physiology-
dc.subject.MESHHippocampus/physiology-
dc.subject.MESHMice-
dc.subject.MESHMice, Knockout-
dc.subject.MESHOrgan Culture Techniques-
dc.subject.MESHProtein Subunits/chemistry/physiology-
dc.subject.MESHReceptors, AMPA/*chemistry/*physiology-
dc.subject.MESHSynapses/chemistry/physiology-
dc.subject.MESHSynaptic Transmission/*physiology-
dc.titleCornichon proteins determine the subunit composition of synaptic AMPA receptors.-
dc.typeArticle-
dc.identifier.pmid23522044-
dc.identifier.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3652566/-
dc.contributor.affiliatedAuthor서, 영호-
dc.type.localJournal Papers-
dc.identifier.doi10.1016/j.neuron.2013.01.017-
dc.citation.titleNeuron-
dc.citation.volume77-
dc.citation.number6-
dc.citation.date2013-
dc.citation.startPage1083-
dc.citation.endPage1096-
dc.identifier.bibliographicCitationNeuron, 77(6):1083-1096, 2013-
dc.identifier.eissn1097-4199-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pharmacology
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