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The prognostic significance of growth factors and growth factor receptors in gastric adenocarcinoma.

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dc.contributor.authorKim, JY-
dc.contributor.authorJeon, TJ-
dc.contributor.authorBae, BN-
dc.contributor.authorKwon, JE-
dc.contributor.authorKim, HJ-
dc.contributor.authorPark, K-
dc.contributor.authorShin, E-
dc.date.accessioned2014-05-02T04:31:07Z-
dc.date.available2014-05-02T04:31:07Z-
dc.date.issued2013-
dc.identifier.issn0903-4641-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/9882-
dc.description.abstractWe evaluated growth factors/receptors expression in gastric adenocarcinoma. Immunohistochemistry was used to evaluate epidermal growth factor receptor (EGFR), vascular endothelial growth factor (VEGF), VEGF-D, VEGF receptor (VEGFR)-2, VEGFR-3, transforming growth factor (TGF)-α, TGF-β1, and TGF-β-RII in tissue microarrays of adenocarcinoma, dysplasia, metaplasia, and gastritis. In adenocarcinoma, the expression rates of EGFR, VEGF, VEGF-D, VEGFR-2, VEGFR-3, TGF-α, TGF-β1, and TGF-β-RII were 2.0%, 0%, 10.7%, 4.4%, 11.2%, 26.3%, 9.4%, and 19.5%, respectively. VEGF-D, TGF-α, TGF-β1, and TGF-β-RII expression rate were higher in adenocarcinoma than in other groups. TGF-β-RII expression was correlated with VEGFR-3, VEGF-D, and TGF-α expression in adenocarcinomas. Tumor location, histologic type, stage, lymphatic invasion, perineural invasion, angioinvasion, VEGF-D, and VEGFR-2 expressions were associated with patient survival in a log rank test and advanced stage and positive expression of VEGF-D were poor prognostic factors using Cox analysis. VEGF-D expression may be of prognostic value in gastric adenocarcinoma, whereas EGFR and TGF family expression may only have a minor influence.-
dc.language.isoen-
dc.subject.MESHCloning, Molecular-
dc.subject.MESHFemale-
dc.subject.MESHGene Expression-
dc.subject.MESHHumans-
dc.subject.MESHImmunohistochemistry-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPrognosis-
dc.subject.MESHProportional Hazards Models-
dc.subject.MESHProtein-Serine-Threonine Kinases-
dc.subject.MESHReceptor, Epidermal Growth Factor-
dc.subject.MESHReceptors, Transforming Growth Factor beta-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHStomach Neoplasms-
dc.subject.MESHTissue Array Analysis-
dc.subject.MESHTransforming Growth Factor beta1-
dc.subject.MESHTumor Markers, Biological-
dc.subject.MESHVascular Endothelial Growth Factor D-
dc.subject.MESHVascular Endothelial Growth Factor Receptor-2-
dc.subject.MESHVascular Endothelial Growth Factor Receptor-3-
dc.titleThe prognostic significance of growth factors and growth factor receptors in gastric adenocarcinoma.-
dc.typeArticle-
dc.identifier.pmid23030255-
dc.contributor.affiliatedAuthor권, 지은-
dc.type.localJournal Papers-
dc.identifier.doi10.1111/j.1600-0463.2012.02942.x-
dc.citation.titleAPMIS : acta pathologica, microbiologica, et immunologica Scandinavica-
dc.citation.volume121-
dc.citation.number2-
dc.citation.date2013-
dc.citation.startPage95-
dc.citation.endPage104-
dc.identifier.bibliographicCitationAPMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 121(2). : 95-104, 2013-
dc.identifier.eissn1600-0463-
dc.relation.journalidJ009034641-
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Journal Papers > School of Medicine / Graduate School of Medicine > Pathology
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