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The expression of metabolism-related proteins in phyllodes tumors.

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dc.contributor.authorKwon, JE-
dc.contributor.authorJung, WH-
dc.contributor.authorKoo, JS-
dc.date.accessioned2014-05-02T04:43:40Z-
dc.date.available2014-05-02T04:43:40Z-
dc.date.issued2013-
dc.identifier.issn1010-4283-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/9885-
dc.description.abstractThe purpose of this study was to investigate the association between the expression of hypoxia-inducible factor (HIF)-1α, insulin-like growth factor (IGF)-1, glucose transporter 1 (Glut-1), carbonic anhydrase IX (CAIX), and monocarboxylate transporter (MCT)4, which are metabolism-related proteins in phyllodes tumors (PTs), and clinicopathologic factors and its implication. We used tissue microarrays to analyze 207 PTs and performed immunohistochemical staining against the glycolysis-related molecules HIF-1α, IGF-1, Glut-1, CAIX, and MCT4. We then compared the immunohistochemical results and clinicopathologic parameters. The expressions of HIF-1α, Glut-1, CAIX, and MCT4 in the stromal component of PTs increased (P = 0.019, P < 0.001, P = 0.045, and P < 0.001, respectively) with increasing tumor grade. According to univariate analysis, factors associated with shorter disease-free survival were Glut-1 expression (P = 0.001) and MCT4 expression (P < 0.001) in the stromal component, and the factors associated with shorter overall survival were IGF-1 expression (P = 0.012), Glut-1 expression (P < 0.001), CAIX expression (P = 0.039), and MCT4 expression (P < 0.001) in the stromal component. Our investigation of stromal expression of the metabolism-related proteins HIF-1α, IGF-1, Glut-1, CAIX, and MCT4 revealed that, as the PT grade increased, the stromal expression of HIF-1α, Glut-1, CAIX, and MCT4 significantly increased. This result suggested that increasing PT grade is associated with increased glycolysis in the stromal component.-
dc.language.isoen-
dc.subject.MESHAdult-
dc.subject.MESHAntigens, Neoplasm/metabolism-
dc.subject.MESHBreast Neoplasms/*metabolism/mortality-
dc.subject.MESHCarbonic Anhydrases/metabolism-
dc.subject.MESHDisease-Free Survival-
dc.subject.MESH*Energy Metabolism-
dc.subject.MESHFemale-
dc.subject.MESHGlucose Transporter Type 1/metabolism-
dc.subject.MESHGlycolysis-
dc.subject.MESHHumans-
dc.subject.MESHHypoxia-Inducible Factor 1, alpha Subunit/metabolism-
dc.subject.MESHInsulin-Like Growth Factor I/metabolism-
dc.subject.MESHMonocarboxylic Acid Transporters/metabolism-
dc.subject.MESHMuscle Proteins/metabolism-
dc.subject.MESHNeoplasm Grading-
dc.subject.MESHPhyllodes Tumor/*metabolism-
dc.subject.MESHSurvival-
dc.subject.MESHTumor Markers, Biological/metabolism-
dc.titleThe expression of metabolism-related proteins in phyllodes tumors.-
dc.typeArticle-
dc.identifier.pmid22986897-
dc.contributor.affiliatedAuthor권, 지은-
dc.type.localJournal Papers-
dc.identifier.doi10.1007/s13277-012-0518-9-
dc.citation.titleTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine-
dc.citation.volume34-
dc.citation.number1-
dc.citation.date2013-
dc.citation.startPage115-
dc.citation.endPage124-
dc.identifier.bibliographicCitationTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 34(1):115-124, 2013-
dc.identifier.eissn1423-0380-
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Journal Papers > School of Medicine / Graduate School of Medicine > Pathology
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