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Prognostic significance of tetraspanin CD151 in newly diagnosed glioblastomas.

Authors
Lee, D; Suh, YL; Park, TI; Do, IG; Seol, HJ; Nam, DH; Kim, ST
Citation
Journal of surgical oncology, 107(6):646-652, 2013
Journal Title
Journal of surgical oncology
ISSN
0022-47901096-9098
Abstract
BACKGROUND: Tetraspanin CD151 is a positive effector of cancer invasion and metastasis.



METHODS: We investigated the expression of CD151 by immunohistochemistry in 211 cases of grade I to IV gliomas. Additionally, we performed O6-methylguanin-DNA methyltransferase (MGMT) methylation analysis using real-time methylation-specific PCR in 36 patients with glioblastoma, and the prognostic significance of these biomarkers in glioblastomas was evaluated.



RESULTS: Overexpression of CD151 was observed in a significant proportion (55.6%) of glioblastomas, while CD151 was rarely overexpressed in most of grade I to III glial tumors. CD151 overexpression was closely associated with MGMT methylation (P = 0.014), and it was a prognostic factor for predicting worse overall survival (OS; P = 0.002) and progression-free survival (PFS; P = 0.043). We also found that combination of CD151 overexpression and MGMT methylation better stratified the patients' OS (P = 0.001) and PFS (P = 0.009). In multivariate analysis, CD151 overexpression was an independent prognostic factor for predicting OS over MGMT methylation (P = 0.012).



CONCLUSIONS: CD151 seems to have a critical role for high-grade progression in astroglial tumors. Furthermore, CD151 is a good tissue marker that can be used easily in a daily practice for predicting worse prognosis in patients with glioblastoma.
MeSH terms
AdultAgedAntigens, CD151/*metabolismBrain/surgeryBrain Neoplasms/genetics/*metabolism/mortality/therapy*Cerebral CortexChemoradiotherapy, AdjuvantDNA MethylationFemaleFollow-Up StudiesGene Expression Regulation, NeoplasticGlioblastoma/genetics/*metabolism/mortality/therapyGlioma/genetics/metabolism/mortality/therapyHumansImmunohistochemistryMaleMiddle AgedMultivariate AnalysisO(6)-Methylguanine-DNA Methyltransferase/geneticsPrognosisReal-Time Polymerase Chain ReactionSurvival AnalysisTumor Markers, Biological/*metabolismUp-Regulation
DOI
10.1002/jso.23249
PMID
22926763
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Journal Papers > School of Medicine / Graduate School of Medicine > Pathology
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