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CCL21 attenuates HSV-induced inflammation through up-regulation of CD8+ memory cells.

DC Field Value Language
dc.contributor.authorChoi, B-
dc.contributor.authorLim, HC-
dc.contributor.authorLee, ES-
dc.contributor.authorAnower, AK-
dc.contributor.authorSohn, S-
dc.date.accessioned2014-05-07T01:00:56Z-
dc.date.available2014-05-07T01:00:56Z-
dc.date.issued2013-
dc.identifier.issn0171-2985-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/9900-
dc.description.abstractCCR7 and its ligand, CCL21, are known to establish microenvironments for the initiation of immune responses in secondary lymphoid tissue. It has also been reported that CCR7 ligand gene-deleted mice have defects in lymphocyte homing. In addition, the injection of the CCR7 ligand was shown to induce the expression of memory T cells. In this study, we analyzed the expression of CCR7 and its ligand in HSV-induced Behçet's disease (BD)-like inflammation of mice. Additionally, plasmids containing the CCR7 ligand CCL19 or CCL21, pcDNA3.1-CCL19 or pcDNA3.1-CCL21, respectively, were injected into symptomatic mice, and changes in the population of memory T cells were determined. After administration of pcDNA3.1-CCL21, the frequencies of CD8+CD44+, CD8+CD62L- memory T cells were significantly up-regulated and the symptoms were not deteriorated when compared to the control vector injected group. Specifically, the difference in frequencies of CCR7+ peripheral blood mononuclear cells between active BD patients and inactive BD patients was similar to that of HSV-induced BD-like mice. These results suggest that CCR7, its ligand, and CD8+ memory cells are correlated with the regulation of BD symptoms.-
dc.language.isoen-
dc.subject.MESHAdult-
dc.subject.MESHAnimals-
dc.subject.MESHBehcet Syndrome/genetics/*immunology/pathology/virology-
dc.subject.MESHCD8-Positive T-Lymphocytes/*immunology/pathology-
dc.subject.MESHCercopithecus aethiops-
dc.subject.MESHChemokine CCL21/genetics/*immunology-
dc.subject.MESHDisease Models, Animal-
dc.subject.MESHFemale-
dc.subject.MESHHerpes Simplex/genetics/*immunology/pathology/virology-
dc.subject.MESHHerpesvirus 1, Human/*immunology-
dc.subject.MESHHumans-
dc.subject.MESH*Immunologic Memory-
dc.subject.MESHInflammation/genetics/immunology/pathology/virology-
dc.subject.MESHMale-
dc.subject.MESHMice-
dc.subject.MESHMice, Inbred ICR-
dc.subject.MESHMiddle Aged-
dc.subject.MESHReceptors, CCR7/genetics/immunology-
dc.subject.MESHUp-Regulation/*immunology-
dc.subject.MESHVero Cells-
dc.titleCCL21 attenuates HSV-induced inflammation through up-regulation of CD8+ memory cells.-
dc.typeArticle-
dc.identifier.pmid22884357-
dc.identifier.urlhttp://linkinghub.elsevier.com/retrieve/pii/S0171-2985(12)00167-2-
dc.contributor.affiliatedAuthor이, 은소-
dc.contributor.affiliatedAuthor손, 성향-
dc.type.localJournal Papers-
dc.identifier.doi10.1016/j.imbio.2012.07.003-
dc.citation.titleImmunobiology-
dc.citation.volume218-
dc.citation.number4-
dc.citation.date2013-
dc.citation.startPage579-
dc.citation.endPage590-
dc.identifier.bibliographicCitationImmunobiology, 218(4):579-590, 2013-
dc.identifier.eissn1878-3279-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Dermatology
Journal Papers > School of Medicine / Graduate School of Medicine > Microbiology
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