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Therapeutic potency of Poly I:C in HSV-induced inflammation through up-regulation of IL-15 receptor alpha.

Authors
Choi, J; Lee, ES; Choi, B; Sohn, S
Citation
Immunobiology, 218(9):1119-1130, 2013
Journal Title
Immunobiology
ISSN
0171-29851878-3279
Abstract
Interleukin-15 receptor alpha (IL-15Rα) forms stable complex with IL-15 on the cell surface of activated monocytes and mediates the proliferation of memory CD8+ T cells. Recent studies informed that polyinosinic:polycytidylic acid (Poly I:C) is an immunostimulant which boosts the generation of memory T cells through induction of IL-15Rα. The aim of this study is to evaluate the relevance of IL-15Rα in Herpes simplex virus (HSV)-induced Behçet's disease (BD) mouse model and BD patients. The frequencies of IL-15Rα expression in PBMCs of BD patients and BD-like symptomatic mice were analyzed by flow cytometry. In addition, Poly I:C supplementation could reduce inflammation through the up-regulation of memory T cells and IL-15Rα+ cells accompany with down-regulation of pro-inflammatory cytokine, IL-17A in BD mice. In BD patients, the frequencies of IL-15Rα expression in PBMCs were also significantly different between the inactive and active disease states. These results suggest that IL-15Rα is a relevant factor in BD.
MeSH terms
AnimalsBehcet Syndrome/etiology/immunology/*therapyCells, CulturedDisease Models, AnimalFemaleFlow CytometryHumansImmunologic Memory/drug effectsInflammation/immunologyInterleukin-15 Receptor alpha Subunit/genetics/immunology/*metabolismInterleukin-17/genetics/metabolismMaleMiceMice, Inbred ICRMiddle AgedPoly I-C/*therapeutic useSimplexvirus/immunologyT-Lymphocytes/drug effects/*immunologyUp-Regulation/drug effectsVirus Activation/genetics/immunology
DOI
10.1016/j.imbio.2013.03.005
PMID
23618691
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Dermatology
Journal Papers > School of Medicine / Graduate School of Medicine > Microbiology
AJOU Authors
이, 은소손, 성향
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