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Effects of education on the progression of early- versus late-stage mild cognitive impairment.

Authors
Ye, BS; Seo, SW; Cho, H; Kim, SY; Lee, JS; Kim, EJ; Lee, Y; Back, JH; Hong, CH; Choi, SH; Park, KW; Ku, BD; Moon, SY; Kim, S; Han, SH; Lee, JH; Cheong, HK; Na, DL
Citation
International psychogeriatrics, 25(4):597-606, 2013
Journal Title
International psychogeriatrics
ISSN
1041-61021741-203X
Abstract
BACKGROUND: Highly educated participants with normal cognition show lower incidence of Alzheimer's disease (AD) than poorly educated participants, whereas longitudinal studies involving AD have reported that higher education is associated with more rapid cognitive decline. We aimed to evaluate whether highly educated amnestic mild cognitive impairment (aMCI) participants show more rapid cognitive decline than those with lower levels of education.



METHODS: A total of 249 aMCI patients enrolled from 31 memory clinics using the standard assessment and diagnostic processes were followed with neuropsychological evaluation (duration 17.2 ± 8.8 months). According to baseline performances on memory tests, participants were divided into early-stage aMCI (-1.5 to -1.0 standard deviation (SD)) and late-stage aMCI (below -1.5 SD) groups. Risk of AD conversion and changes in neuropsychological performances according to the level of education were evaluated.



RESULTS: Sixty-two patients converted to AD over a mean follow-up of 1.43 years. The risk of AD conversion was higher in late-stage aMCI than early-stage aMCI. Cox proportional hazard models showed that aMCI participants, and late-stage aMCI participants in particular, with higher levels of education had a higher risk of AD conversion than those with lower levels of education. Late-stage aMCI participants with higher education showed faster cognitive decline in language, memory, and Clinical Dementia Rating Sum of Boxes (CDR-SOB) scores. On the contrary, early-stage aMCI participants with higher education showed slower cognitive decline in MMSE and CDR-SOB scores.



CONCLUSIONS: Our findings suggest that the protective effects of education against cognitive decline remain in early-stage aMCI and disappear in late-stage aMCI.
MeSH terms
AgedAged, 80 and overAlzheimer Disease/diagnosis/psychologyAmnesia/*psychologyCognition Disorders/diagnosis/*psychologyDisease Progression*Educational StatusFemaleHumansLogistic ModelsMaleMild Cognitive Impairment/diagnosis/*psychologyNeuropsychological TestsProportional Hazards ModelsPsychiatric Status Rating ScalesRetrospective StudiesRisk FactorsSeverity of Illness IndexTime Factors
DOI
10.1017/S1041610212002001
PMID
23207181
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Psychiatry & Behavioural Sciences
Journal Papers > School of Medicine / Graduate School of Medicine > Neurology
Journal Papers > School of Medicine / Graduate School of Medicine > Preventive Medicine & Public Health
AJOU Authors
이, 윤환홍, 창형문, 소영
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