90 243

Cited 10 times in

Discordance between liver biopsy and FibroTest in assessing liver fibrosis in chronic hepatitis B.

Park, MS; Kim, BK; Cheong, JY; Kim, DJ; Park, JY; Kim, do Y; Ahn, SH; Han, KH; Chon, CY; Kim, SU
PloS one, 8(2):e55759-e55759, 2013
Journal Title
PloS one
BACKGROUND AND AIMS: The FibroTest (FT) demonstrated excellent diagnostic performance in the prediction of liver fibrosis in patients with chronic hepatitis B (CHB). Here, we aimed to identify predictors of discordance between FT and liver biopsy (LB) in Asian patients with CHB.

METHODS: Consecutive patients with CHB who underwent both LB and FT on the same day between 2007 and 2010 were recruited from three medical institutes. Laboratory evaluations including specific parameters for calculating FT score, such as α2-macroglobulin, apolipoprotein A1, haptoglobin, γ-glutamyl transpeptidase, and total bilirubin levels, were obtained. The Batts and Ludwig scoring system was used for histological analysis.

RESULTS: A total of 330 patients (200 male and 130 female) were analyzed. Discordances of at least two fibrosis stages between FT and LB were observed in 30 (9.1%) patients; using FT, fibrosis was underestimated in 25 patients and overestimated in 5 patients with reference to LB. Patients with discordance had a higher proportion of F3-4 (P<0.001) and F4 (P = 0.012) compared with those with nondiscordance. The discordance rate was significantly higher in those with F3-4 than those with F1-2 (15.4% vs. 3.0%, P<0.001). Multivariate analysis demonstrated F3-4 at LB as the only independent factor for discordance (P<0.001; odds ratio 5.95). After adjusting fibrosis stages, neither necroinflammatory activity on histology nor serum ALT level influenced FT values independently.

CONCLUSION: Advanced fibrosis stage (F3-4) is the sole factor of discordance between FT and LB in Asian patients with CHB.
MeSH terms
AdultAgedAged, 80 and overApolipoprotein A-I/bloodAsian Continental Ancestry GroupBilirubin/bloodBiological Markers/*bloodBiopsy*Diagnostic Techniques, Digestive SystemFemaleHaptoglobins/metabolismHepatitis B virus/pathogenicityHepatitis B, Chronic/blood/complications/*pathologyHumansInflammation/blood/etiology/*pathologyLiver Cirrhosis/blood/etiology/*pathology/surgeryMaleMiddle AgedYoung Adultalpha-Macroglobulins/metabolismgamma-Glutamyltransferase/blood
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Gastroenterology
AJOU Authors
정, 재연
Full Text Link
Files in This Item:
RIS (EndNote)
XLS (Excel)


해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.