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Association of on-treatment serum hepatitis B surface antigen level with sustained virological response to nucleos(t)ide analog in patients with hepatitis B e-antigen positive chronic hepatitis B.

Authors
Kim, SS; Lee, D; Lee, MH; Cheong, JY; Cho, SW
Citation
Hepatology research : the official journal of the Japan Society of Hepatology, 43(3):219-227, 2013
Journal Title
Hepatology research : the official journal of the Japan Society of Hepatology
ISSN
1386-63461872-034X
Abstract
Aim:  This study evaluated the on-treatment serum hepatitis B surface antigen (HBsAg) level during nucleos(t)ide analog (NUC) therapy and the correlation with off-treatment sustained virological response (SVR). Methods:  Fifty-one consecutive patients with hepatitis B e-antigen (HBeAg) positive chronic hepatitis B who achieved HBeAg loss/seroconversion after NUC therapy and completed 12 months or more of additional therapy were included. Serum HBsAg and hepatitis B virus (HBV) DNA levels were determined at baseline, 3, 6, 9 and 12 months, and at the end of treatment. SVR was defined as HBV DNA levels of less than 10 000 copies/mL until 6 or 12 months off-treatment without reappearance of HBeAg. Results:  Twenty-two (43.1%) and 13 (25.5%) patients maintained SVR at 6 and 12 months off-treatment, respectively. In univariate analyses, a decline of HBsAg of 0.5 log(10)  IU/mL or less at 6 months (P = 0.006) and 12 months (P = 0.013), the mean change in HBsAg level at 6 months (P = 0.024), and lamivudine or entecavir treatment (P = 0.019) were significant predictive factors for SVR at 6 months off-treatment. A decline of HBsAg of 0.5 log(10)  IU/mL or less at 6 months and lamivudine or entecavir treatment were independent factors on multivariate analyses (odds ratio [OR], 16.67; 95% confidence interval [CI], 1.86-142.86 [P = 0.012]; and OR, 14.83; 95% CI, 1.18-185.73 [P = 0.036]; respectively). Conclusion:  On-treatment serum HBsAg level predicted early off-treatment SVR to NUC therapy in patients infected with genotype C.
DOI
10.1111/j.1872-034X.2012.01065.x
PMID
22835015
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Gastroenterology
AJOU Authors
김, 순선정, 재연조, 성원
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