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Effect of DA-9701, a novel prokinetic agent, on stress-induced delayed gastric emptying and hormonal changes in rats.

Authors
Jung, YS; Kim, MY; Lee, HS; Park, SL; Lee, KJ
Citation
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 25(3):254-259, 2013
Journal Title
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
ISSN
1350-19251365-2982
Abstract
BACKGROUND: DA-9701 is a novel prokinetic agent formulated with Pharbitis Semen and Corydalis Tuber. This study aimed to evaluate the effect of DA-9701 on stress-induced delay in gastric emptying and changes in plasma adrenocorticotropic hormone and ghrelin levels in rats.



METHODS: Changes in gastric emptying in response to different durations of stress were evaluated. Gastric emptying was compared between the following groups: (i) nonstressed vehicle- or DA-9701-treated group, (ii) nonstressed vehicle- or mosapride-treated group, (iii) 2-h stressed vehicle- or DA-9701-treated group, and (iv) 2-h stressed vehicle- or mosapride-treated group. Water immersion restraint stress was used as the stressor. DA-9701 or mosapride at 3 mg kg(-1) was administered to the rats after subjecting them to 2-h stress, and then gastric emptying was measured using the phenol red method.



KEY RESULTS: Gastric emptying was significantly delayed in the 2-h stressed group compared with the nonstressed group. Mosapride administration resulted in significant recovery from the stress-induced delay in gastric emptying. Gastric emptying in the rats that underwent 2-h stress followed by DA-9701 administration was not significantly different from that in the nonstressed group. The plasma adrenocorticotropic hormone and active ghrelin levels in the 2-h stressed group were significantly higher than those in the nonstressed group. These increases were significantly inhibited by DA-9701.



CONCLUSIONS & INFERENCES: The administration of DA-9701 improved delayed gastric emptying and inhibited the hormonal changes induced by stress, suggesting that DA-9701 can be used as a gastroprokinetic agent for the treatment of delayed gastric emptying, particularly that associated with stress.
MeSH terms
Adrenocorticotropic Hormone/*bloodAnimalsDisease Models, AnimalEnzyme-Linked Immunosorbent AssayGastric Emptying/*drug effects/physiologyGastrointestinal Agents/pharmacologyGastroparesis/blood/*drug therapy/psychologyGhrelin/*bloodKineticsMalePlant Preparations/*pharmacologyRatsRats, Sprague-DawleyStress, Psychological/complications
DOI
10.1111/nmo.12053
PMID
23216854
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Gastroenterology
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