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Association of polymorphism in MicroRNA 219-1 with clearance of hepatitis B virus infection.

DC Field Value Language
dc.contributor.authorCheong, JY-
dc.contributor.authorShin, HD-
dc.contributor.authorKim, YJ-
dc.contributor.authorCho, SW-
dc.date.accessioned2014-05-15-
dc.date.available2014-05-15-
dc.date.issued2013-
dc.identifier.issn0146-6615-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/9958-
dc.description.abstractPolymorphisms in the primary microRNA region may be associated with natural course of hepatitis B virus (HBV) infection. This study evaluated if the mircoRNA 219-1 (miR-219-1) polymorphism can influence the susceptibility towards persistence of HBV infection and the progression to hepatocellular carcinoma (HCC) in patients with chronic HBV infection. A total of 1,439 individuals having either past or present evidence of HBV infection were enrolled for the study. The subjects were divided into four groups; (1) spontaneous recovery (n = 404), (2) chronic HBV carrier (n = 313), (3) chronic HBV carrier with cirrhosis (n = 305), and (4) hepatocellular carcinoma (n = 417). Genotyping was performed at three polymorphic variants (rs421446, rs107822, and rs213210) in the pri-miRNA region of miR-219-1. The rs421446 T allele was found to be strongly associated with HBV clearance (OR = 0.73, P = 0.0005 in a codominant model and OR = 0.67, P = 0.0009 in a dominant model, OR = 0.69, P = 0.04 in a recessive model, respectively). The rs107822 G allele was also found to be associated with HBV clearance (OR = 0.79, P = 0.008 in a codominant model and OR = 0.72, P = 0.01 in a dominant model, respectively). In haplotype analysis, ht2 (T-G-T) and ht1 (C-A-C) were found to be in significant association with the clearance of HBV. However, no significant association was observed between miR-219-1 polymorphism and the risk of HCC occurrence. This result suggests that polymorphisms in the pri-miRNA region of miR-219-1 might be a genetic factor for HBV clearance after infection.-
dc.language.isoen-
dc.subject.MESHAdolescent-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHCarcinoma, Hepatocellular/genetics/immunology/virology-
dc.subject.MESHCarrier State/immunology/virology-
dc.subject.MESHCase-Control Studies-
dc.subject.MESHFemale-
dc.subject.MESHHepatitis B/complications/*genetics/*immunology/virology-
dc.subject.MESHHepatitis B virus/*immunology-
dc.subject.MESHHumans-
dc.subject.MESHLiver Cirrhosis/complications/genetics/immunology/virology-
dc.subject.MESHLiver Neoplasms/genetics/immunology/virology-
dc.subject.MESHMale-
dc.subject.MESHMicroRNAs/*genetics/*immunology-
dc.subject.MESHMiddle Aged-
dc.subject.MESH*Polymorphism, Genetic-
dc.subject.MESHYoung Adult-
dc.titleAssociation of polymorphism in MicroRNA 219-1 with clearance of hepatitis B virus infection.-
dc.typeArticle-
dc.identifier.pmid23508906-
dc.contributor.affiliatedAuthor정, 재연-
dc.contributor.affiliatedAuthor조, 성원-
dc.type.localJournal Papers-
dc.identifier.doi10.1002/jmv.23551-
dc.citation.titleJournal of medical virology-
dc.citation.volume85-
dc.citation.number5-
dc.citation.date2013-
dc.citation.startPage808-
dc.citation.endPage814-
dc.identifier.bibliographicCitationJournal of medical virology, 85(5):808-814, 2013-
dc.identifier.eissn1096-9071-
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Journal Papers > School of Medicine / Graduate School of Medicine > Gastroenterology
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