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A genome-wide association study identified new variants associated with the risk of chronic hepatitis B.

Authors
Kim, YJ; Kim, HY; Lee, JH; Yu, SJ; Yoon, JH; Lee, HS; Kim, CY; Cheong, JY; Cho, SW; Park, NH; Park, BL; Namgoong, S; Kim, LH; Cheong, HS; Shin, HD
Citation
Human molecular genetics, 22(20):4233-4238, 2013
Journal Title
Human molecular genetics
ISSN
0964-69061460-2083
Abstract
Hepatitis B virus (HBV) infection is the predominant risk factor for chronic hepatitis B (CHB), liver cirrhosis (LC) and hepatocellular carcinoma (HCC). Recently, several genome-wide association studies (GWASs) of CHB identified human leukocyte antigen (HLA) loci, including HLA-DP and HLA-DQ in Asian populations, as being associated with the risk of CHB. To confirm and identify the host genetic factors related to CHB infection, we performed another GWAS using a higher-density chip in Korean CHB carriers. We analyzed 1400 samples from Korean population (400 CHB cases and 1000 population controls) using a higher-density GWAS chip [1 140 419 single nucleotide polymorphisms (SNPs)]. In subsequent replication analysis, we further analyzed in an independent study of a Korean CHB cohort consisting of 2909 Korean samples (971 cases and 1938 controls). Logistic regression methods were used for statistical analysis adjusting for age and sex as covariates. This study identified two new risk-associated loci for CHB on the HLA region of chromosome 6, e.g. rs652888 on euchromatic histone-lysine-methyltransferase 2 (EHMT2, P = 7.07 × 10(-13)) and rs1419881 on transcription factor 19 (TCF19, P = 1.26 × 10(-18)). Conditional analysis with nearby HLA CHB loci that were previously known, confirmed the independent genetic effects of these two loci on CHB. Conclusion: The GWAS and the subsequent validation study identified new variants associated with the risk of CHB. These findings may advance the understanding of genetic susceptibility to CHB.
MeSH terms
Age FactorsAsian Continental Ancestry Group/geneticsCase-Control StudiesChromosomes, Human, Pair 6FemaleGenetic Predisposition to DiseaseGenetic Variation*Genome-Wide Association StudyHepatitis B, Chronic/*geneticsHistocompatibility Antigens/*geneticsHumansMalePolymorphism, Single NucleotideReproducibility of ResultsRisk FactorsSex DistributionTranscription Factors/*genetics
DOI
10.1093/hmg/ddt266
PMID
23760081
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Gastroenterology
AJOU Authors
정, 재연조, 성원
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