2026-09-23T16:57:04Zhttps://repository.ajou.ac.kr/oai/request

oai:repository.ajou.ac.kr:201003/118352024-10-11T02:21:24Zcom_201003_14372com_201003_14368col_201003_14373

Bridging the lesioned spinal cord using hydrogel Hong, Le Thi Anh 김, 병곤 대학원 의생명과학과 201225142 Hong, Le Thi Anh Spinal cord injury hydrogel extracullular matrix I. INTRODUCTION 1 A. Spinal Cord Injury 1 B. Cavity formation and the importance of bridging lesion after spinal cord injury. 2 C. Bridging cavity using biomaterials 3 D. Injectable hydrogel for contusive injury model 4 E. Aims of Study 5 II. MATERIALS AND METHODS 6 1. Animal and surgical procedures 6 2. Poly (phosphazene) hydrogel injection 6 3. Tissue processing 6 4. Immunohistochemistry 7 5. Three dimensional reconstruction of lesion cavity 7 6. Zymography 7 7. Behavioral assessment 8 III. RESULTS 10 1. Hydrogel injection prevent cavity formation after contusive spinal cord injury 10 2. Hydrogel injection suppress microglial activation 4 week after injection 14 3. Remodelling of extracellular matrix by I-5 injection 16 4. Matrixmetallo-proteinase-9 ( MMP-9) involved in ECM remodelling 20 5. Perivascular fibroblasts are a major source of the newly formed ECM at 1 and 4 week 23 6. I-5 injection promotes functional recovery 25 IV. DISCUSSION 28 V. CONCLUSION 31 Master 2015-10-28T02:56:30Z 2015-10-28T02:56:30Z 2015 2015 Thesis Theses http://repository.ajou.ac.kr/handle/201003/11835 http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000020728 000000020728 en text/plain