2026-09-23T00:36:53Zhttps://repository.ajou.ac.kr/oai/request

oai:repository.ajou.ac.kr:201003/13152024-10-11T02:17:38Zcom_201003_14369com_201003_14368col_201003_14371

유, 희석 김, 현진 대학원 의학과 200424174 김, 현진 2011-01-26T09:54:48Z 2011-01-26T09:54:48Z 2010 2010 http://repository.ajou.ac.kr/handle/201003/1315 http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000010928 000000010928 "Objective: Aberrant expression of the cell surface proteoglycan, syndecan-1, is found in many malignancies. The current study describes the immunohistochemical study of syndecan-1 expression in normal, hyperplastic, and malignant endometrial tissues for evaluation of application as a parameter of cancer progression in patients with endometrial hyperplasia. Methods: Immunohistochemical staining of syndecan-1 was performed in 101 formalin fixed, paraffin embedded sections of normal, hyperplastic, and malignant endometrial tissues. We analyzed specimens from patients with normal endometrium (NE, n=10) as controls, and those of simple hyperplasia (SH, n=20), complex hyperplasia without atypia (CH, n=20), atypical hyperplasia (AH, n=20), and endometrial cancer (EC, n=31). Results: The mean rank of expression scores based on the frequency of syndecan-1 staining were 31.6, 20.5, 52.9, 72.1, and 62.1 for NE, SH, CH, AH and EC, respectively (p < 0.001). Syndecan-1 expression was significantly greater in CH (p < 0.001) or AH (p < 0.001) than in SH, and significantly greater in AH compared to CH (p=0.028). Syndecan-1 is more frequently expressed in CH (p=0.042), AH (p < 0.001), or EC (p=0.002) than in NE. Syndecan-1 expression did not differ significantly between NE and SH (p=0.248). Conclusion: Syndecan-1 expression appears to be useful as a predictive indicator of endometrial carcinogenesis from normal endometrium or endometrial hyperplasia to endometrial cancer. " Approved for entry into archive by Hyun Chul Cho (hccho@ajou.ac.kr) on 2011-01-26T09:54:48Z (GMT) No. of bitstreams: 1 000000010928.pdf: 1708035 bytes, checksum: 43666f53b8c35167aeb27b01e223ac3a (MD5) Made available in DSpace on 2011-01-26T09:54:48Z (GMT). No. of bitstreams: 1 000000010928.pdf: 1708035 bytes, checksum: 43666f53b8c35167aeb27b01e223ac3a (MD5) Submitted by Hyun Chul Cho (hccho@ajou.ac.kr) on 2011-01-26T09:54:48Z No. of bitstreams: 1 000000010928.pdf: 1708035 bytes, checksum: 43666f53b8c35167aeb27b01e223ac3a (MD5) "ABSTRACT ⅰ TABLE OF CONTENTS ⅲ LIST OF FIGURES ⅳ LIST OF TABLES ⅴ Ⅰ. INTRODUCTION 1 Ⅱ. PATIENTS AND METHODS 3 A. Patients and tissue samples 3 B. Immunohistochemical study 5 C. Staining evaluation 5 D. Statistical analysis 6 Ⅲ. RESULTS 7 A. Patient characteristics 7 B. Expression of syndecan-1 8 Ⅳ. DISCUSSION 12 REFERENCE 15 국문요약 19 " Doctor application/pdf en The Expression of Syndecan-1 is Related to the Risk of Endometrial Hyperplasia Progressing to Endometrial Carcinoma 자궁내막증식증 및 자궁내막암과 syndecan-1의 발현과의 관련성 Thesis Theses Syndecan-1 자궁내막증식증 자궁내막암 2010 9999-12-31 9999-12-31