2026-09-23T13:26:08Zhttps://repository.ajou.ac.kr/oai/request

oai:repository.ajou.ac.kr:201003/13262024-10-11T02:17:38Zcom_201003_14369com_201003_14368col_201003_14370

황, 진순 고, 정희 대학원 의학과 200824464 고, 정희 2011-01-26T11:19:24Z 2011-01-26T11:19:24Z 2010 2010 http://repository.ajou.ac.kr/handle/201003/1326 http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000010733 000000010733 "We assessed bone mineral density (BMD) and body composition in 121 Korean girls with central precocious puberty (CPP) before, during, and after 1 year of treatment with gonadotropin-releasing hormone (GnRH) agonist. BMD, bone mineral content (BMC), lean body mass (LBM), and fat mass (FM) were measured at baseline and after 1 year of treatment with dual energy x-ray absorptiometry (DEXA) and were expressed as standard deviation scores (SDS). Bone age and biochemical and hormonal profiles were assessed at baseline, after 6 months and 1 year of treatment. Mean BMC and LBM were significantly lower than zero at baseline while FM and percent body fat (% FM) were higher than zero at baseline for both chronological and bone age. After 1 year of treatment, the differences for chronological age were decreased while the differences for bone age were persisted. The BMD SDS of each region of interest (ROI) including lumbar spine for chronological age were significantly higher than zero at baseline and increased after 1 year of treatment, while BMD SDS for bone age was significantly lower than zero at baseline and increased after 1 year of treatment. Girls with CPP showed high %FM before and after GnRH agonist treatment for both chronological and bone age. The risk of obesity seems to be started before GnRH agonist treatment. Through this study, we concluded that pituitary-gonadal axis suppression by GnRH agonist does not reverse the progression of bone mass acquisition in children with CPP." Approved for entry into archive by Hyun Chul Cho (hccho@ajou.ac.kr) on 2011-01-26T11:19:24Z (GMT) No. of bitstreams: 1 000000010733.pdf: 864933 bytes, checksum: 9343919ee8c49b345606e28e9741e6e6 (MD5) Made available in DSpace on 2011-01-26T11:19:24Z (GMT). No. of bitstreams: 1 000000010733.pdf: 864933 bytes, checksum: 9343919ee8c49b345606e28e9741e6e6 (MD5) Submitted by Hyun Chul Cho (hccho@ajou.ac.kr) on 2011-01-26T11:19:24Z No. of bitstreams: 1 000000010733.pdf: 864933 bytes, checksum: 9343919ee8c49b345606e28e9741e6e6 (MD5) "ABSTRACT i TABLE OF CONTENTS ii LIST OF FIGURES iii LIST OF TABLES iv ABBREVIATION v I. INTRODUCTION 1 II. SUBJECTS AND METHODS 3 A. PATIENTS 3 B. METHODS 3 C. STATISTICS 5 III. RESULTS 6 A. POPULATION CHARACTERISTICS 6 B. BONE MINERAL DENSITY CHANGES OF EACH REGION OF INTEREST 7 C. BODY COMPOSITION CHANGES 11 IV. DISCUSSION 12 V. CONCLUSION 16 REFERENCES 17 국문요약 21" Master en Changes in BMD and Body Composition in Children with Central Precocious Puberty Before and After Treatment with GnRH Agonist GnRH agonist로 치료한 특발성 진성 성조숙증 여아에서 치료전과 치료 1년 후에 DEXA로 측정한 골밀도와 체성분의 변화 Thesis Theses central precocious puberty GnRH agonist bone mineral density obesity DEXA 2010 9999-12-31 9999-12-31