2026-09-22T15:30:44Zhttps://repository.ajou.ac.kr/oai/request

oai:repository.ajou.ac.kr:201003/14512024-10-11T02:17:37Zcom_201003_14369com_201003_14368col_201003_14371

Nrf2-Dependent Overexpression of Sulfiredoxin and Peroxiredoxin III in Human Lung Cancer, Especially Squamous Cell Carcinoma 인체 편평상피 세포암 조직에서 Nrf2 에 의존한 Sulfiredoxin 과 Peroxiredoxin III의 과 발현 양상과 임상적 의의 김, 영선 황, 성철 대학원 의학과 104930 김, 영선 "TABLE OF CONTENTS ABSTRACT i TABLE OF CONTENTS iii LIST OF FIGURES v ABBREVIATION vi Ⅰ. INTRODUCTION 1 Ⅱ. MATERIALS AND METHODS 6 A. Materials 6 B. Subjects 6 C. Cell culture and viability 7 D. Transfection and depletion of siRNA 7 E. Immunocytochemistry 8 F. Co-immunoprecipitation and immunoblot analysis 8 G. Two-dimensional electrophoresis 9 H. Subcellular fractionation 10 I. Immunohistochemistry 10 J. Statistical analysis 11 Ⅲ. RESULTS 12 A. Localization of Prx III and Srx in A549 cells 12 B. Oxidation of Prx III in mink lung epithelial cells 12 C. Srx dependent regulation of Prx III oxidation in A549 cells 15 D. Srx is translocated into the mitochondria under oxidative stress 15 E. Overexpression of Prx I and III isoforms in human lung cancer 19 F. Nrf2 dependent expression of ARE-proteins in human lung cancer 19 G. Overexpression of Srx in human lung cancer 19 H. Survival of patients with lung cancer based on Srx expression 26 I. Expression of Srx in human lung cancer tissue 26 Ⅳ. DISCUSSION 28 Ⅴ. CONCLUSION 30 REFFERENCE 32 국문요약 40 " Doctor 2011-02-08T08:03:13Z 2011-02-08T08:03:13Z 2010 2010 Thesis Theses http://repository.ajou.ac.kr/handle/201003/1451 http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000010432 000000010432 en