<?xml version="1.0" encoding="UTF-8"?><?xml-stylesheet type="text/xsl" href="static/style.xsl"?><OAI-PMH xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/ http://www.openarchives.org/OAI/2.0/OAI-PMH.xsd"><responseDate>2026-09-23T13:03:24Z</responseDate><request verb="GetRecord" identifier="oai:repository.ajou.ac.kr:201003/1521" metadataPrefix="oai_dc">https://repository.ajou.ac.kr/oai/request</request><GetRecord><record><header><identifier>oai:repository.ajou.ac.kr:201003/1521</identifier><datestamp>2024-10-11T02:17:30Z</datestamp><setSpec>com_201003_14369</setSpec><setSpec>com_201003_14368</setSpec><setSpec>col_201003_14371</setSpec></header><metadata><oai_dc:dc xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:doc="http://www.lyncode.com/xoai" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:dc="http://purl.org/dc/elements/1.1/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
<dc:title>Which Gene is a Dominant Predictor of Response during FOLFOX Chemotherapy for the Treatment of Metastatic Colorectal Cancer, MTHFR or XRCC1 Gene?</dc:title>
<dc:title>다제 병합요법이 시행된 전이성 대장암 환자에서 XRCC1 유전자 및 MTHFR 유전자 변이와 약물반응과의 관계</dc:title>
<dc:creator>김, 주형</dc:creator>
<dc:contributor>서, 광욱</dc:contributor>
<dc:contributor>대학원 의학과</dc:contributor>
<dc:contributor>102984</dc:contributor>
<dc:contributor>김, 주형</dc:contributor>
<dc:subject>대장암</dc:subject>
<dc:subject>유전자변이</dc:subject>
<dc:subject>예후인자</dc:subject>
<dc:subject>X-ray cross-complementing1 유전자</dc:subject>
<dc:subject>Methylenetetrahydrofolate reductase 유전자</dc:subject>
<dc:description>"국문요약 -------------------------------------------	i

차례 -----------------------------------------------	iv

그림 차례 -------------------------------------------	v

표 차례----------------------------------------------	vi

       I. 서론 ------------------------------------------	1

       II. 연구대상 및 방법------------------------------	4

              A. 연구대상 --------------------------------	4

              B. 항암화학요법 방법 및 치료효과의 판정 -----	4

              C. 유전자 다형성 분석 -----------------------	6

                   1. DNA preparation and amplification      

                       MTHFR and XRCC1-------------------	6

                   2. Nucleotide sequencing----------------	7

                   3. Fluorescence-based direct sequencing.-7

              D. 통계학적 분석 ---------------------------	11

       III. 결과 -----------------------------------------	12

              A. 대상 환자의 특성--------------------------12    

              B. 유전자 변이 양상-------------------------	14

              C. 항암화학요법에 대한 반응정도-------------	17

              D. 유전자 변이양상과 항암화학요법 반응 정도간의 

                  상관관계---------------------------------	18

       IV. 고찰 ----------------------------------------	22

        V. 결론 ----------------------------------------	28

참고문헌 --------------------------------------------	29

ABSTRACT------------------------------------------	34

"</dc:description>
<dc:description>Doctor</dc:description>
<dc:date>2011-03-03T01:55:02Z</dc:date>
<dc:date>2011-03-03T01:55:02Z</dc:date>
<dc:date>2006</dc:date>
<dc:date>2006</dc:date>
<dc:type>Thesis</dc:type>
<dc:type>Theses</dc:type>
<dc:identifier>http://repository.ajou.ac.kr/handle/201003/1521</dc:identifier>
<dc:identifier>http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000000901</dc:identifier>
<dc:identifier>000000000901</dc:identifier>
<dc:language>ko</dc:language>
</oai_dc:dc>
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