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oai:repository.ajou.ac.kr:201003/17852024-10-11T02:17:37Zcom_201003_14369com_201003_14368col_201003_14371

중뇌동맥을 결찰한 흰쥐의 산화망간조영증강 자기공명영상(MONERI) 연구 전, 평 김, 세혁 대학원 의학과 200524478 전, 평 MONERI 산화망간나노입자 세포자멸사 T1 조영제 뇌경색 "국문요약 ⅰ 차례 ⅲ 그림 차례 ⅳ 표 차례 ⅵ Ⅰ. 서론 1 Ⅱ. 연구대상 및 방법 4 A. 연구대상 4 B. 연구방법 6 1. 산화망간 나노입자 조영제 6 2. 영구폐색 국소 뇌허혈 동물모델 8 3. 산화망간 나노입자 조영제를 이용한 자기공명영상 10 4. 시간에 따른 신호 대 잡음비의 측정 11 5. H & E 염색 13 6. TUNEL 염색 13 7. 통계분석 14 Ⅲ. 결과 15 A. 중뇌동맥 폐색 후 흰쥐의 MONEMRI 영상소견 15 B. 뇌경색 이후 각 영역별 신호 대 잡음비의 시간에 따른 변화 25 C. 뇌손상 조직의 H&E 염색표본과 MR영상 비교 28 D. 뇌손상 조직의 TUNEL 염색표본과 MONEMRI 비교 32 Ⅳ. 고찰 35 Ⅴ. 결론 38 참고문헌 39 ABSTRACT 44 그림 차례 Fig. 1. Schematic diagram of study protocol 5 Fig. 2. A manufacturing process of MnO nanoparticle 7 Fig. 3. Anatomy structure of cerebral artery in rat brain 9 Fig. 4. Localization of selected ROIs for SNR measurement 12 Fig. 5. Coronal T1 images at pre-occlusion, 3hrs, 6hrs, 24hrs, 72hrs and 1wk after the occlusion of right MCA in rat 17 Fig. 6. Coronal T2 images at pre-occlusion, 3hrs, 6hrs, 24hrs, 72hrs and 1wk after the occlusion of right MCA in rat 18 Fig. 7. Coronal diffusion-weighted images(DWI) at pre- occlusion, 3hrs, 6hrs, 24hrs, 72hrs and 1wk after the occlusion of right MCA in rat 19 Fig. 8. Coronal T2* images at pre-occlusion, 3hrs, 6hrs, 24hrs, 72hrs and 1wk after the occlusion of right MCA in rat 20 Fig. 9. Coronal MnO enhanced T1 images at pre- occlusion, 3hrs, 6hrs, 24hrs, 72hrs and 1wk after the occlusion of right MCA in rat 21 Fig. 10. Coronal T2 images of MONEMRI at pre-occlusion, 3hrs, 6hrs, 24hrs, 72hrs and 1wk after the occlusion of right MCA in rat 22 Fig. 11. Coronal DWI of MONEMRI at pre-occlusion, 3hrs, 6hrs, 24hrs, 72hrs and 1wk after the occlusion of right MCA in rat 23 Fig. 12. Coronal T2* of MONEMRI at pre-occlusion, 3hrs, 6hrs, 24hrs, 72hrs and 1wk after the occlusion of right MCA in rat 24 Fig. 13. Serial SNR of cerebral cortex, basal ganglia and peripheral zone of infarcted area 26 Fig. 14. Comparing of coronal MnO enhanced T1 image and corresponding H&E stained slide in rat brains after 3hrs, 6hrs, 24hrs, 72hrs and 1wk 29 Fig. 15. Hematoxylin and eosin staining of the ischemic injure brain 31 Fig. 16. In situ detection of apoptoic cell death after MCA occlusion 33 Fig. 17. High magnification of TUNEL positive cell. 34 표 차례 Table 1. Serial SNR of cerebral cortex and basal ganglia 27" Doctor 2011-03-17T01:50:16Z 2011-03-17T01:50:16Z 2009 2009 Thesis Theses http://repository.ajou.ac.kr/handle/201003/1785 http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000010020 000000010020 ko