2026-09-26T09:45:42Zhttps://repository.ajou.ac.kr/oai/requestoai:repository.ajou.ac.kr:201003/22712024-10-11T02:17:38Zcom_201003_14372com_201003_14368col_201003_14373
한국인 전신성 홍반성 루푸스에서 Fcγ 수용체 유전자들의 다형성
김, 건영
서, 창희
대학원 의생명과학과
200824379
김, 건영
Fcγ 수용체
다형성
전신성 홍반성 루푸스
"국문요약 ················································································· ⅰ
차 례 ················································································· ⅳ
그림차례 ················································································· ⅵ
표 차례 ················································································· ⅶ
Ⅰ. 서 론 ·················································································· 1
Ⅱ. 재료 및 방법 ········································································ 5
A. 대상 환자군의 선별과 genomic DNA 준비 ·································· 5
1. 루푸스 환자군과 대조군 ····················································· 5
2. 환자군과 대조군으로부터 채혈 ············································· 5
3. Genomic DNA 추출 ························································ 5
B. 단일염기다형성 탐색 ····························································· 5
1. Fcg 수용체 ⅡA 유전자의 전사조절 부위와 exon4 부위에서 다형성의 유전자형 탐색 ································································· 5
2. Fcg 수용체 ⅡB 유전자의 exon5 와 intorn5 부위에서 다형성의 유전자형 탐색 ············································································· 6
C. 단일염기다형성의 유전자형 결정 ·············································· 7
1. Fcg 수용체 ⅡA 유전자의 전사조절 부위와 exon4, 그리고 Fcg 수용체 ⅡB 유전자의 exon5와 intorn5 부위에서 다형성의 유전자형 결정 ···· 7
E. 통계분석 ··········································································· 8
Ⅲ. 결 과 ················································································· 9
A. Fcg 수용체 ⅡA 유전자와 Fcg 수용체 ⅡB 유전자의 다형성 확인 ········ 9
1. Fcg 수용체 ⅡA 유전자의 전사조절 부위와 exon4 부위에서 다형성의 유전자형 확인 ··································································· 9
2. Fcg 수용체 ⅡB 유전자의 exon5 부위와 intron5 부위에서 다형성의 유전자형 확인 ································································· 10
3. Fcg 수용체 ⅡA 유전자와 Fcg 수용체 ⅡB 유전자의 다형성 통계분석 ·················································································· 10
B. 다형성의 유전자형 결정 ······················································· 11
1. Fcg 수용체 ⅡB 유전자의 exon5 부위와 intron5 부위에서 다형성의 유전자형 결정 ································································ 11
C. 루푸스 환자군과 정상 대조군의 임상적 특징 ································· 15
D. Fcg 수용체 ⅡB 유전자의 단일염기다형성의 유전자형과 임상적 특징과의 상관관계 ·········································································· 17
Ⅳ. 고 찰 ················································································· 19
Ⅴ. 결 론 ················································································ 22
참고 문헌 ················································································ 23
영문요약 ·················································································· 30
"
Master
2011-04-13T05:38:02Z
2011-04-13T05:38:02Z
2010
2010
Thesis
Theses
http://repository.ajou.ac.kr/handle/201003/2271
http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000010922
000000010922
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