2026-09-22T23:02:52Zhttps://repository.ajou.ac.kr/oai/request

oai:repository.ajou.ac.kr:201003/43142024-10-11T02:17:38Zcom_201003_14369com_201003_14368col_201003_14370

Prognostic Factors in Transitional Cell Carcinoma of Upper Urinary Tract after Radical Nephroureterectomy 근치적 신요관전적출술을 시행받은 상부요로 이행세포암에서 예후인자 김, 영균 김, 세중 대학원 의학과 104846 김, 영균 Urinary Tract Cancer Transitional Cell Carcinoma Prognosis 예후인자 상부요로이행세포암 근치적 신요관적출술 Purpose : The aim of this study was to evaluate the prognostic factors for survival in patients treated surgically for transitional cell carcinoma of the upper urinary tract (UUT-TCC). Materials and Methods : I retrospectively reviewed the medical records of 87 patients (64 men and 23 women, mean age of 62.2 years) with UUT-TCC who had undergone radical nephroureterectomy at our institution between June 1994 and June 2009. The median follow-up period was 32 months. The prognostic significance of various clinicopathological variables for recurrence-free and cancer-specific survival was analyzed using univariate and multivariate analysis. Results : Of total 87 patients, 21 patients (24.1%) developed local recurrence or distant metastasis and 16 patients (18.4%) died during the follow-up period. The 5-year recurrence-free and cancer-specific survival rates were 74.6% and 75.2%, respectively. On univariate analysis, hydronephrosis, T stage, N stage, and lymphovascular invasion (LVI) were significant prognostic factors for recurrence-free and cancer-specific survival. On multivariate analysis, T stage and LVI were independent prognostic factors for recurrence-free and cancer-specific survival. Conclusions : The T stage and LVI are independent prognostic factors for recurrence-free and cancer-specific survival in patients with UUT-TCC treated by radical nephroureterectomy. These findings would be helpful for guiding the decisions about adjuvant therapies and surveillance interval. ABSTRACT ⅰ TABLE OF CONTENTS ⅲ LIST OF TABLES iv Ⅰ. INTRODUCTION 1 Ⅱ. MATERIALS AND METHODS 2 Ⅲ. RESULTS 4 Ⅳ. DISCUSSION 9 Ⅴ. CONCLUSION 14 REFERENCES 15 국문요약 19 Master 2011-10-28T06:16:15Z 2011-10-28T06:16:15Z 2011 2011 Thesis Theses http://repository.ajou.ac.kr/handle/201003/4314 http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000011184 000000011184 en