2026-09-21T21:22:15Zhttps://repository.ajou.ac.kr/oai/request

oai:repository.ajou.ac.kr:201003/43332024-10-11T02:17:39Zcom_201003_14369com_201003_14368col_201003_14370

Effect-site consentration of remifentanil for nasotracheal versus orotracheal intubation during propofol target-controlled infusion Propofol 목표농도조절주입 중 경비 또는 경구 기관내 삽관을 위한 remifentanil의 효과처농도 비교 최, 이화 김, 종엽 대학원 의학과 200924258 최, 이화 경비 기관내삽관 경구 기관내삽관 목표농도조절주입 remifentanil propofol nasotracheal intubation orotracheal intubation Background: The purpose of this study was to determine the effect-site concentrations of remifentanil required for acceptable nasotracheal (NT) intubation in adults after propofol target-controlled infusion (TCI) without neuromuscular blocking agent, and whether or not these concentrations differ from those for orotracheal (OT) intubation. Methods: Fifty patients were assigned to receive either OT intubation (OT group, n = 25) or NT intubation (NT group, n = 25). Anaesthesia was induced with propofol TCI at the effect-site concentration of 5.0 μg/ml. Two minutes later, the predetermined effect-site concentration of remifentanil was started (from 4.5 ng/ml) using Dixon’s up-and-down method. Tracheal intubation was performed during the remifentanil infusion 2 min after beginning. Acceptable intubation was defined as excellent or good intubating conditions. Results: EC50 ± SD of remifentanil in the OT and NT groups was 5.58 ± 0.75 ng/ml and 6.08 ± 0.75 ng/ml, respectively; there was no statistical significance between the groups (P = 0.277). Using isotonic regression, EC50 (95% CI) of remifentanil in the OT and NT groups was 5.00 (3.34-7.46) ng/ml and 5.75 (3.66-7.84) ng/mlv, respectively (P = 0.592). Conclusion: The effect-site concentration of remifentanil for acceptable NT intubation was 6.08 ng/ml in 50% of adults during propofol TCI at an effect-site concentration of 5.0 μg/ml without neuromuscular blocking agent. The predicted effect-site concentration of remifentanil for NT intubation was not different from OT intubation. ABSTRACTⅰ TABLE OF CONTENTSⅱ LIST OF FIGURES ⅲ LIST OF TABLESⅳ TEXTⅴ Ⅰ. INTRODUCTION 1 Ⅱ. METHODS 2 Ⅲ. RESULTS 6 Ⅳ. DISCUSSION 9 V. CONCLUSION 17 REFERENCES ⅵ 국문요약 ⅶ Master 2011-11-01T01:28:57Z 2011-11-01T01:28:57Z 2011 2011 Thesis Theses http://repository.ajou.ac.kr/handle/201003/4333 http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000011257 000000011257 en