2026-09-23T15:54:40Zhttps://repository.ajou.ac.kr/oai/request

oai:repository.ajou.ac.kr:201003/43642024-10-11T02:17:39Zcom_201003_14369com_201003_14368col_201003_14371

Comparison of the Incidence and Severity of Cough after Alfentanil and Remifentanil Injection Alfentanil과 remifentanil 정주 후 나타나는 기침의 발생 빈도와 정도 비교 조, 한범 이, 숙영 대학원 의학과 104247 조, 한범 alfentanil remifentanil opioid induced cough Introduction: Intravenous administration of fentanyl derivatives can induce cough paradoxically. This study examined the incidence and severity of cough after a bolus of alfentanil and remifentanil. Methods: Four-hundred sixty five patients, aged 18-70 years, were allocated randomly to three groups to receive alfentanil 10 μg/kg, remifentanil 1 μg/kg, or an equal volume of 0.9% saline intravenously over 10 s. Any episode of cough was classified as coughing and graded as mild (1-2), moderate (3-4) or severe (5 or more). Results: The overall incidence of cough was higher in the opioid groups than the saline group. The remifentanil group [39/150 patients; 26.0%, (95% CI, 19.6-33.6%)] showed a higher incidence than the alfentanil group [11/152 patients; 7.2%, (95% CI, 0.4-12.6%)] (P < 0.001). There was no significant difference in the severity of cough between alfentanil and remifentanil group. Conclusion: This study demonstrated that the equipotent boluses of alfentanil and remifentanil induced coughing, even though the incidence of cough after alfentanil administration was lower than that after remifentanil administration. ABSTRACT i TABLE OF CONTENTS ii LIST OF TABLES iii LIST OF FIGURE iv ABBREVIATIONS v I. INTRODUCTION 1 II. PATIENTS AND METHODS 3 III. RESULTS 5 IV. DISCUSSION 12 REFERENCES 17 국문요약 21 Doctor 2011-11-07T04:22:47Z 2011-11-07T04:22:47Z 2011 2011 Thesis Theses http://repository.ajou.ac.kr/handle/201003/4364 http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000011484 000000011484 en