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In vivo diagnosis of plaque erosion and calcified nodule in patients with acute coronary syndrome by intravascular optical coherence tomography.

Jia, H; Abtahian, F; Aguirre, AD; Lee, S; Chia, S; Lowe, H; Kato, K; Yonetsu, T; Vergallo, R; Hu, S; Tian, J; Lee, H; Park, SJ; Jang, YS; Raffel, OC; Mizuno, K; Uemura, S; Itoh, T; Kakuta, T; Choi, SY; Dauerman, HL; Prasad, A; Toma, C; McNulty, I; Zhang, S; Yu, B; Fuster, V; Narula, J; Virmani, R; Jang, IK
Journal of the American College of Cardiology, 62(19):1748-1758, 2013
Journal Title
Journal of the American College of Cardiology
OBJECTIVES: The aim of this study was to characterize the morphological features of plaque erosion and calcified nodule in patients with acute coronary syndrome (ACS) by optical coherence tomography (OCT).

BACKGROUND: Plaque erosion and calcified nodule have not been systematically investigated in vivo.

METHODS: A total of 126 patients with ACS who had undergone pre-intervention OCT imaging were included. The culprit lesions were classified as plaque rupture (PR), erosion (OCT-erosion), calcified nodule (OCT-CN), or with a new set of diagnostic criteria for OCT.

RESULTS: The incidences of PR, OCT-erosion, and OCT-CN were 43.7%, 31.0%, and 7.9%, respectively. Patients with OCT-erosion were the youngest, compared with those with PR and OCT-CN (53.8 ± 13.1 years vs. 60.6 ± 11.5 years, 65.1 ± 5.0 years, p = 0.005). Compared with patients with PR, presentation with non-ST-segment elevation ACS was more common in patients with OCT-erosion (61.5% vs. 29.1%, p = 0.008) and OCT-CN (100% vs. 29.1%, p < 0.001). The OCT-erosion had a lower frequency of lipid plaque (43.6% vs. 100%, p < 0.001), thicker fibrous cap (169.3 ± 99.1 μm vs. 60.4 ± 16.6 μm, p < 0.001), and smaller lipid arc (202.8 ± 73.6° vs. 275.8 ± 60.4°, p < 0.001) than PR. The diameter stenosis was least severe in OCT-erosion, followed by OCT-CN and PR (55.4 ± 14.7% vs. 66.1 ± 13.5% vs. 68.8 ± 12.9%, p < 0.001).

CONCLUSIONS: Optical coherence tomography is a promising modality for identifying OCT-erosion and OCT-CN in vivo. The OCT-erosion is a frequent finding in patients with ACS, especially in those with non-ST-segment elevation ACS and younger patients. The OCT-CN is the least common etiology for ACS and is more common in older patients. (The Massachusetts General Hospital Optical Coherence Tomography Registry; NCT01110538).
MeSH terms
Acute Coronary Syndrome/*diagnosis/epidemiology/etiologyAgedCalcinosis/complications/*diagnosis/epidemiologyCoronary AngiographyCoronary Vessels/*pathologyDiagnosis, DifferentialFemaleHumansIncidenceMaleMiddle AgedPlaque, Atherosclerotic/complications/*diagnosis/epidemiologyReproducibility of ResultsTomography, Optical Coherence/*methodsWorld Health
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Journal Papers > School of Medicine / Graduate School of Medicine > Cardiology
AJOU Authors
최, 소연
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