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Transforming growth factor (TGF)-beta1-induced human endometrial stromal cell decidualization through extracellular signal-regulated kinase and Smad activation in vitro: peroxisome proliferator-activated receptor gamma acts as a negative regulator of TGF-beta1.

DC Field Value Language
dc.contributor.authorChang, HJ-
dc.contributor.authorLee, JH-
dc.contributor.authorHwang, KJ-
dc.contributor.authorKim, MR-
dc.contributor.authorChang, KH-
dc.contributor.authorPark, DW-
dc.contributor.authorMin, CK-
dc.date.accessioned2011-01-06T05:30:20Z-
dc.date.available2011-01-06T05:30:20Z-
dc.date.issued2008-
dc.identifier.issn0015-0282-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/1022-
dc.description.abstractOBJECTIVE: To investigate the effect of transforming growth factor (TGF)-beta1 on the extracellular signal-regulated kinase (ERK) and Smad pathway and the role of peroxisome proliferator-activated receptor (PPAR)-gamma in cultured human endometrial stromal cells.



DESIGN: Experimental study.



SETTING: Infertility center of a tertiary university hospital. MATERIAL(S): Human endometrial tissues obtained by hysterectomy from patients with conditions other than endometrial diseases.



INTERVENTION(S): Endometrial stromal cells were cultured under normal laboratory conditions. TGF-beta1, rosiglitazone (PPARgamma agonist), and PD98059 (ERK inhibitor) were added to endometrial stromal cell culture according to experimental purposes.



MAIN OUTCOME MEASURE(S): Cell count, PRL expression, Smad and ERK phosphorylation, cyclooxygenase (COX)-2 expression, and prostaglandin E(2) (PGE(2)) release.



RESULT(S): TGF-beta1 inhibited cellular proliferation and induced the expressions of COX-2, PGE(2), and PRL of cultured human endometrial stromal cells. These effects may be mediated by Smad and ERK phosphorylation. Treatment with rosiglitazone, a PPARgamma agonist, reversed the TGF-beta1 effect by antagonizing the activation of ERK and Smad that was induced by TGF-beta1.



CONCLUSION(S): PPARgamma plays a negative role by directly acting on Smad and ERK phosphorylation in human endometrial cell decidualization that is induced by TGF-beta1 in vitro.
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dc.language.isoen-
dc.subject.MESHAdult-
dc.subject.MESHCells, Cultured-
dc.subject.MESHDown-Regulation-
dc.subject.MESHEndometrium-
dc.subject.MESHExtracellular Signal-Regulated MAP Kinases-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHPPAR gamma-
dc.subject.MESHSignal Transduction-
dc.subject.MESHSmad Proteins-
dc.subject.MESHStromal Cells-
dc.subject.MESHTransforming Growth Factor beta1-
dc.titleTransforming growth factor (TGF)-beta1-induced human endometrial stromal cell decidualization through extracellular signal-regulated kinase and Smad activation in vitro: peroxisome proliferator-activated receptor gamma acts as a negative regulator of TGF-beta1.-
dc.typeArticle-
dc.identifier.pmid18082740-
dc.identifier.urlhttp://linkinghub.elsevier.com/retrieve/pii/S0015-0282(07)03482-6-
dc.contributor.affiliatedAuthor황, 경주-
dc.contributor.affiliatedAuthor김, 미란-
dc.contributor.affiliatedAuthor장, 기홍-
dc.type.localJournal Papers-
dc.identifier.doi10.1016/j.fertnstert.2007.09.010-
dc.citation.titleFertility and sterility-
dc.citation.volume90-
dc.citation.number4 Suppl.-
dc.citation.date2008-
dc.citation.startPage1357-
dc.citation.endPage1365-
dc.identifier.bibliographicCitationFertility and sterility, 90(4 Suppl.). : 1357-1365, 2008-
dc.identifier.eissn1556-5653-
dc.relation.journalidJ000150282-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Obstetrics & Gynecology
Journal Papers > School of Medicine / Graduate School of Medicine > Medical Humanities & Social Medicine
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