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The role of peroxiredoxin III in the ototoxic drug-induced mitochondrial apoptosis of cochlear hair cells.

Authors
Choi, HS; Park, KJ; Hwang, SC; Park, HY; Kim, YS; Park, K
Citation
Acta oto-laryngologica, 128(9):944-951, 2008
Journal Title
Acta oto-laryngologica
ISSN
0001-64891651-2251
Abstract
CONCLUSION: Peroxiredoxin (Prx) III plays a protective role in cisplatin- and gentamicin-induced apoptosis via a mitochondria-dependent pathway in cochlear hair cells. OBJECTIVES: The aim of the present study was to investigate the effects of the depletion of endogenous Prx III on oxidative damage to mitochondrial components and on apoptotic events with the use of RNA interference. MATERIALS AND METHOD: . Depletion of Prx III was done by RNA interference in cochlear hair cells (UB/OC-1), and cells were exposed to ototoxic drugs (cisplatin or gentamicin). We then compared the apoptotic signaling between Prx III-depleted and control cells. RESULTS: The depletion of Prx III resulted in increased intracellular ROS levels accompanied by enhanced apoptosis by ototoxic drugs. The Prx III-depleted cells showed mitochondrial membrane potential collapse, cytochrome c release, and caspase activation.
MeSH terms
Anti-Bacterial Agents/pharmacologyAntineoplastic Agents/pharmacologyApoptosis/drug effectsApoptosis/physiology*Cell Culture TechniquesCisplatin/pharmacologyCochlea/drug effectsCochlea/metabolismCochlea/pathology*Gentamicins/pharmacologyHair Cells, Auditory/drug effectsHair Cells, Auditory/metabolismHair Cells, Auditory/pathology*HumansIn Situ Nick-End LabelingMitochondria/drug effectsMitochondria/metabolismMitochondria/pathology*Oxidative Stress/drug effectsOxidative Stress/physiology*Peroxiredoxins/physiology*RNA InterferenceReactive Oxygen Species/metabolism
DOI
10.1080/00016480701805463
PMID
19086304
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Otolaryngology
Journal Papers > School of Medicine / Graduate School of Medicine > Pulmonary & Critical Care Medicine
Journal Papers > School of Medicine / Graduate School of Medicine > Medical Science
AJOU Authors
박광주황성철박헌이박기현
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