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Prostate-specific antigen velocity in healthy Korean men with initial PSA levels of 4.0 ng/mL or less.

Authors
Ham, WS; Kang, DR; Kim, YS; Seong, do H; Kim, SJ; Cheon, SH; Cho, IR; Cho, JS; Kim, CI; Choi, YD
Citation
Urology, 72(1):99-103, 2008
Journal Title
Urology
ISSN
0090-42951527-9995
Abstract
OBJECTIVES: To assess the longitudinal changes in serial prostate-specific antigen (PSA) levels in healthy Korean men with initial PSA levels of 4.0 ng/mL.



METHODS: The rate of PSA change or PSA velocity (PSAV) in 24 869 healthy men with an initial PSA level of 4.0 ng/mL or less who were clinically free of genitourinary disease was analyzed at intervals of at least 12 months. The influence of age, initial PSA level, and the interval between measurements was assessed.



RESULTS: The mean age, initial PSA level, interval between measurements, and change in PSA and PSAV was 46.2 years, 0.86 ng/mL, 21.9 months, and 0.03 ng/mL and 0.02 ng/mL/y, respectively. A cumulative frequency plot of PSAV demonstrated that 50%, 95%, and 97% of subjects had a PSAV of 0.01, 0.40, and 0.52 ng/mL/y or less, respectively. The PSAV correlated with age, initial PSA level, and interval between measurements. The percentage of men with a PSAV greater than 0.75 ng/mL/y was 0.61% (151 of 24 869) and was 0.51% (92 of 17 985) for those with an initial PSA level of less than 1.0 ng/mL, 0.86% (50 of 5807) for those with a PSA level of 1.1-2.0 ng/mL, and 0.84% (9 of 1077) for those with an initial PSA level of 2.1-4.0 ng/mL.



CONCLUSIONS: In healthy Korean men with an initial PSA level of 4.0 ng/mL or less, most will have a PSAV of less than 0.75 ng/mL/y. Thus, traditional PSAV cutoff values are not applicable in this population. We propose that a lower PSAV cutoff value should be used to indicate biopsy. Additional large-scale prospective studies, including biopsy data, are required to assess the cutoff value of PSAV for healthy Korean men with a PSA level of 4.0 ng/mL or less.
MeSH terms
AdultAgedHumansKoreaMaleMiddle AgedProstate-Specific Antigen/blood*Reference Values
DOI
10.1016/j.urology.2008.03.002
PMID
18533237
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Urology
AJOU Authors
김, 세중
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