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Efficacy and safety of high concentration lidocaine for trigeminal nerve block in patients with trigeminal neuralgia.

Authors
Han, KR; Kim, C; Chae, YJ; Kim, DW
Citation
International journal of clinical practice, 62(2):248-254, 2008
Journal Title
International journal of clinical practice
ISSN
1368-50311742-1241
Abstract
AIMS: Local anaesthetics, which act as neurolytics and Na(+) channel blockers, have been used for disrupting the neural firings in certain neuropathic pain conditions. This study was undertaken to investigate the clinical outcome of trigeminal nerve block with 10% lidocaine in the management of trigeminal neuralgia (TN). METHODS: Thirty-five patients with primary TN received trigeminal nerve blocks with 10% lidocaine. Success was defined as complete pain relief or mild pain without medication 1 day after the treatment. We followed the patients up every 2 months assessing for pain recurrence, sensory changes and other complications for a total of 37-45 months (median 43 months). RESULTS: Twelve of the 35 patients (34.3%) responded favourably to the treatment and were considered as success. Eleven patients experienced complete pain relief and one could tolerate pain without medication 1 day after the blocks, which lasted for 3-172 weeks. Four patients experienced mildly decreased sensation in the region of the face supplied by the nerve 1 day after the blocks; however, all recovered normal skin sensation in 6 months. There was neither allodynia nor other sensory discomfort. The pain intensity and current pain duration before treatment were significantly different between the two groups. CONCLUSION: Trigeminal nerve block with high concentration lidocaine (10%) is capable of achieving an intermediate period of pain relief, particularly in patients with lower pain intensity and shorter pain duration prior to the procedure.
MeSH terms
AdolescentAdultAgedAnesthetics, Local/administration & dosage*Anesthetics, Local/adverse effectsFemaleHumansLidocaine/administration & dosage*Lidocaine/adverse effectsMaleMiddle AgedNerve Block/adverse effectsNerve Block/methods*Pain Measurement/methodsTreatment OutcomeTrigeminal Neuralgia/therapy*
DOI
10.1111/j.1742-1241.2007.01568.x
PMID
18036166
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Anesthesiology & Pain Medicine
AJOU Authors
한경림김찬채윤정
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