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Prevention of rocuronium-induced withdrawal movement in children: a comparison of remifentanil with alfentanil.

Kim, JY; Kwak, HJ; Park, KS; Song, JS
Paediatric anaesthesia, 18(3):245-250, 2008
Journal Title
Paediatric anaesthesia
BACKGROUND: This study was designed to compare the efficacy of remifentanil and alfentanil without the venous occlusion technique in preventing the withdrawal response associated with rocuronium injection in children.

METHODS: One hundred and twenty children aged between 3 and 10 years were randomly allocated into one of four groups to receive either i.v. remifentanil 0.5 microg.kg(-1) (remi 0.5 group), remifentanil 1 microg.kg(-1) (remi 1.0 group), alfentanil 15 microg.kg(-1) (alfentanil group) or saline 5 ml (saline group). Anesthesia was induced with 2.5% thiopental sodium 5 mg.kg(-1) and the test drug was injected over 30 s. One minute later, 1% rocuronium 0.6 mg.kg(-1) was injected over 5 s and the response was recorded. Mean arterial pressure (MAP) and heart rate (HR) were recorded on arrival in the operating room, before and 1 min after tracheal intubation.

RESULTS: The incidence of withdrawal movement in the saline group (93%) was significantly higher than that in the remi 0.5, remi 1.0, and alfentanil groups (53%, 17%, and 20%, respectively) (P < 0.05). The incidence in the remi 1.0 and alfentanil groups was significantly less than that in the remi 0.5 group (P < 0.05). After intubation, MAP and HR were significantly higher in the saline group than that in remi 1.0 and alfentanil groups.

CONCLUSIONS: Both remifentanil 1 microg.kg(-1) and alfentanil 15 microg.kg(-1) can be used to prevent rocuronium-associated withdrawal movement in children because they are equally effective and attenuate the increase in MAP and HR after intubation.
MeSH terms
Alfentanil/therapeutic use*Analgesics, Opioid/therapeutic use*Androstanols/adverse effects*Blood Pressure/drug effectsChildChild, PreschoolDouble-Blind MethodFemaleHeart Rate/drug effectsHumansIntubation, IntratrachealMaleMovement/drug effects*Neuromuscular Nondepolarizing Agents/adverse effects*Pain/etiologyPain/prevention & controlPiperidines/therapeutic use*Prospective Studies
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Anesthesiology & Pain Medicine
AJOU Authors
김, 종엽박, 관식
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