Objectives: The aim of this study was to examine the usefulness of a fentanyl matrix patch in the management of chronic low back pain.
Summary of Literature Review: Chronic low back pain is a significant disabling disease with high medical costs and socioeconomical effects. Oral medication is a fundamental tool for conservative treatment. The fentanyl matrix patch is currently regarded as an alternative method for oral medication, however, the usefulness of the fentanyl matrix patch has not been fully evaluated.
Materials and Methods: From September 2008 to May 2009, a multicenter, open, prospective observational study was conducted. The inclusion criteria included chronic pain patients that did not respond to conservative pain management. The clinical usefulness was evaluated with pain intensity, and the KEQ-5D (Korean version of Euro QoL-5 dimension).
Results: Overall, 538 patients were included in this study. The pain intensity decreased about 1.84 ± 1.91 at the second visit and further decreased by about 2.52 ± 2.34 at the third visit (p<0.0001). The KEQ-5D score decreased about 0.12 ± 0.18 at the second visit, and decreased further to 0.18 ± 0.24 at the third visit (p<0.0001). The number of patients with adverse effects was 121 (22.49%).
Conclusions: The fentanyl matrix patch improves the pain and disability in patients with chronic low back pain. It is a useful alternative method for the management of chronic low back pain.
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